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Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain
Costimulatory molecules B7 and B7-2 interact with T cell surface receptors CD28/CTLA4 and deliver a costimulatory signal essential for T cell growth. However, the structure basis of this interaction is not known. B7 and B7-2 are members of immunoglobulin (Ig) superfamily and their extracellular port...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1995
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191977/ https://www.ncbi.nlm.nih.gov/pubmed/7535334 |