Focal Contacts as Mechanosensors: Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent Mechanism

The transition of cell–matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, activation of myosin II–driven contractility by a Rho target known as Rho-associated kinase (ROCK) was shown to be e...

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Detalles Bibliográficos
Autores principales: Riveline, Daniel, Zamir, Eli, Balaban, Nathalie Q., Schwarz, Ulrich S., Ishizaki, Toshimasa, Narumiya, Shuh, Kam, Zvi, Geiger, Benjamin, Bershadsky, Alexander D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192034/
https://www.ncbi.nlm.nih.gov/pubmed/11402062

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