T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice

Interleukin-2 (IL-2)-deficient (IL-2-/-) mice develop anemia and colonic inflammatory bowel disease. To elucidate the mechanism of this disease, we have bred IL-2-/- mice to two strains of immunodeficient mice, RAG-2-deficient (RAG-2-/-, lacking B and T cells) and JH- deficient mice (JH-/-, lacking...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1995
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192197/
https://www.ncbi.nlm.nih.gov/pubmed/7595226
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collection PubMed
description Interleukin-2 (IL-2)-deficient (IL-2-/-) mice develop anemia and colonic inflammatory bowel disease. To elucidate the mechanism of this disease, we have bred IL-2-/- mice to two strains of immunodeficient mice, RAG-2-deficient (RAG-2-/-, lacking B and T cells) and JH- deficient mice (JH-/-, lacking B cells). IL-2-/-, RAG-2-/- double- mutant mice are disease free, while IL-2-/-, JH-/- double-mutant mice succumb to bowel disease at the same rate as IL-2-/- littermates. IL-2- /-, JH-/- mice do not, however, succumb to anemia. Thus, spontaneous intestinal inflammation in IL-2-/- mice requires mature T cells, not B cells, while anemia is dependent on B cells.
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spelling pubmed-21921972008-04-16 T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice J Exp Med Articles Interleukin-2 (IL-2)-deficient (IL-2-/-) mice develop anemia and colonic inflammatory bowel disease. To elucidate the mechanism of this disease, we have bred IL-2-/- mice to two strains of immunodeficient mice, RAG-2-deficient (RAG-2-/-, lacking B and T cells) and JH- deficient mice (JH-/-, lacking B cells). IL-2-/-, RAG-2-/- double- mutant mice are disease free, while IL-2-/-, JH-/- double-mutant mice succumb to bowel disease at the same rate as IL-2-/- littermates. IL-2- /-, JH-/- mice do not, however, succumb to anemia. Thus, spontaneous intestinal inflammation in IL-2-/- mice requires mature T cells, not B cells, while anemia is dependent on B cells. The Rockefeller University Press 1995-11-01 /pmc/articles/PMC2192197/ /pubmed/7595226 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice
title T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice
title_full T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice
title_fullStr T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice
title_full_unstemmed T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice
title_short T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice
title_sort t cells, but not b cells, are required for bowel inflammation in interleukin 2-deficient mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192197/
https://www.ncbi.nlm.nih.gov/pubmed/7595226

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