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A naturally occurring soluble isoform of murine Fas generated by alternative splicing

We report a soluble isoform of mouse Fas, which is generated by alternative splicing of Fas mRNA to a newly identified exon located between exons 2 and 3 of the previously published Fas sequence. This splicing event creates a novel Fas transcript, Fas beta, with the potential to encode a truncated f...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192224/
https://www.ncbi.nlm.nih.gov/pubmed/7595210
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collection PubMed
description We report a soluble isoform of mouse Fas, which is generated by alternative splicing of Fas mRNA to a newly identified exon located between exons 2 and 3 of the previously published Fas sequence. This splicing event creates a novel Fas transcript, Fas beta, with the potential to encode a truncated form of the extracellular domain, termed Fas B. In vitro, P815 mastocytoma cells transfected with Fas B become resistant to Fas ligand-induced apoptosis, and the resistance is mediated by a secreted product of the transfected cells. In vivo, Fas beta mRNA expression is correlated inversely with apoptosis among subsets of intrahepatic T lymphocytes, a cell population in which activation-induced T cell apoptosis occurs. We propose that Fas B is a new cytokine that acts physiologically to limit apoptosis induced by Fas ligand.
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spelling pubmed-21922242008-04-16 A naturally occurring soluble isoform of murine Fas generated by alternative splicing J Exp Med Articles We report a soluble isoform of mouse Fas, which is generated by alternative splicing of Fas mRNA to a newly identified exon located between exons 2 and 3 of the previously published Fas sequence. This splicing event creates a novel Fas transcript, Fas beta, with the potential to encode a truncated form of the extracellular domain, termed Fas B. In vitro, P815 mastocytoma cells transfected with Fas B become resistant to Fas ligand-induced apoptosis, and the resistance is mediated by a secreted product of the transfected cells. In vivo, Fas beta mRNA expression is correlated inversely with apoptosis among subsets of intrahepatic T lymphocytes, a cell population in which activation-induced T cell apoptosis occurs. We propose that Fas B is a new cytokine that acts physiologically to limit apoptosis induced by Fas ligand. The Rockefeller University Press 1995-11-01 /pmc/articles/PMC2192224/ /pubmed/7595210 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A naturally occurring soluble isoform of murine Fas generated by alternative splicing
title A naturally occurring soluble isoform of murine Fas generated by alternative splicing
title_full A naturally occurring soluble isoform of murine Fas generated by alternative splicing
title_fullStr A naturally occurring soluble isoform of murine Fas generated by alternative splicing
title_full_unstemmed A naturally occurring soluble isoform of murine Fas generated by alternative splicing
title_short A naturally occurring soluble isoform of murine Fas generated by alternative splicing
title_sort naturally occurring soluble isoform of murine fas generated by alternative splicing
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192224/
https://www.ncbi.nlm.nih.gov/pubmed/7595210