Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides

The blood-brain barrier restricts the passage of many pharmacological agents into the brain parenchyma. Bacterial glycopeptides induce enhanced blood-brain barrier permeability when they are present in the subarachnoid space during meningitis. By presenting such glycopeptides intravenously, blood-br...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1995
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192296/
https://www.ncbi.nlm.nih.gov/pubmed/7561677
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collection PubMed
description The blood-brain barrier restricts the passage of many pharmacological agents into the brain parenchyma. Bacterial glycopeptides induce enhanced blood-brain barrier permeability when they are present in the subarachnoid space during meningitis. By presenting such glycopeptides intravenously, blood-brain barrier permeability in rabbits was enhanced in a reversible time- and dose-dependent manner to agents < or = 20 kD in size. Therapeutic application of this bioactivity was evident as enhanced penetration of the antibiotic penicillin and the magnetic resonance imaging contrast agent gadolinium-diethylene-triamine- pentaacetic acid into the brain parenchyma.
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spelling pubmed-21922962008-04-16 Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides J Exp Med Articles The blood-brain barrier restricts the passage of many pharmacological agents into the brain parenchyma. Bacterial glycopeptides induce enhanced blood-brain barrier permeability when they are present in the subarachnoid space during meningitis. By presenting such glycopeptides intravenously, blood-brain barrier permeability in rabbits was enhanced in a reversible time- and dose-dependent manner to agents < or = 20 kD in size. Therapeutic application of this bioactivity was evident as enhanced penetration of the antibiotic penicillin and the magnetic resonance imaging contrast agent gadolinium-diethylene-triamine- pentaacetic acid into the brain parenchyma. The Rockefeller University Press 1995-10-01 /pmc/articles/PMC2192296/ /pubmed/7561677 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides
title Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides
title_full Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides
title_fullStr Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides
title_full_unstemmed Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides
title_short Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides
title_sort penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192296/
https://www.ncbi.nlm.nih.gov/pubmed/7561677

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