The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression

Site-specific recombination of immunoglobulin and T cell receptor gene segments in B and T lymphocytes is dependent on the expression of two recombinant activation genes, Rag-1 and Rag-2. Here, we show that RAG-1 protein turnover in pre-B cells depends on the expression of RAG-2. The apparent half-l...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1996
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192496/
https://www.ncbi.nlm.nih.gov/pubmed/8666930
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description Site-specific recombination of immunoglobulin and T cell receptor gene segments in B and T lymphocytes is dependent on the expression of two recombinant activation genes, Rag-1 and Rag-2. Here, we show that RAG-1 protein turnover in pre-B cells depends on the expression of RAG-2. The apparent half-life of RAG-1 protein is increased when RAG-2 is not expressed in differentiating pre-B cells.
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spelling pubmed-21924962008-04-16 The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression J Exp Med Articles Site-specific recombination of immunoglobulin and T cell receptor gene segments in B and T lymphocytes is dependent on the expression of two recombinant activation genes, Rag-1 and Rag-2. Here, we show that RAG-1 protein turnover in pre-B cells depends on the expression of RAG-2. The apparent half-life of RAG-1 protein is increased when RAG-2 is not expressed in differentiating pre-B cells. The Rockefeller University Press 1996-04-01 /pmc/articles/PMC2192496/ /pubmed/8666930 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression
title The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression
title_full The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression
title_fullStr The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression
title_full_unstemmed The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression
title_short The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression
title_sort half-life of rag-1 protein in precursor b cells is increased in the absence of rag-2 expression
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192496/
https://www.ncbi.nlm.nih.gov/pubmed/8666930

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