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A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis

Dendritic cells (DC), the most efficient antigen-presenting cells, are well equipped for activation of naive CD4+ T cells by their expression of high levels of major histocompatibility complex and costimulator molecules. We now demonstrate that some DC are equally well equipped for killing these sam...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192509/
https://www.ncbi.nlm.nih.gov/pubmed/8666935
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collection PubMed
description Dendritic cells (DC), the most efficient antigen-presenting cells, are well equipped for activation of naive CD4+ T cells by their expression of high levels of major histocompatibility complex and costimulator molecules. We now demonstrate that some DC are equally well equipped for killing these same T cells. Murine splenic DC consist of both conventional CD8alpha- DC and a major population of CD8alpha+ DC. Whereas CD8- DC induce a vigorous proliferative response in CD4 T cells, CD8+ DC induce a lesser response that is associated with marked T cell apoptosis. By using various mixtures of T cells and DC from Fas- mutant lpr/lpr mice and Fas-ligand (FasL) mutant gld/gld mice, we show this death is due to interaction of Fas on activated T cells with FasL on CD8+ DC. Furthermore, we show by direct surface staining that CD8+ DC, but not CD8- DC, express FasL at high levels. These findings indicate that FasL+ CD8+ DC are a specialized subgroup of DC with a role in the regulation of the response of primary peripheral T cells.
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spelling pubmed-21925092008-04-16 A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis J Exp Med Articles Dendritic cells (DC), the most efficient antigen-presenting cells, are well equipped for activation of naive CD4+ T cells by their expression of high levels of major histocompatibility complex and costimulator molecules. We now demonstrate that some DC are equally well equipped for killing these same T cells. Murine splenic DC consist of both conventional CD8alpha- DC and a major population of CD8alpha+ DC. Whereas CD8- DC induce a vigorous proliferative response in CD4 T cells, CD8+ DC induce a lesser response that is associated with marked T cell apoptosis. By using various mixtures of T cells and DC from Fas- mutant lpr/lpr mice and Fas-ligand (FasL) mutant gld/gld mice, we show this death is due to interaction of Fas on activated T cells with FasL on CD8+ DC. Furthermore, we show by direct surface staining that CD8+ DC, but not CD8- DC, express FasL at high levels. These findings indicate that FasL+ CD8+ DC are a specialized subgroup of DC with a role in the regulation of the response of primary peripheral T cells. The Rockefeller University Press 1996-04-01 /pmc/articles/PMC2192509/ /pubmed/8666935 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis
title A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis
title_full A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis
title_fullStr A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis
title_full_unstemmed A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis
title_short A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis
title_sort subclass of dendritic cells kills cd4 t cells via fas/fas-ligand- induced apoptosis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192509/
https://www.ncbi.nlm.nih.gov/pubmed/8666935