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Characterization of apoptosis-resistant antigen-specific T cells in vivo
Clonal deletion via activation-induced apoptosis (AIA) of antigen- specific T cells (ASTC) plays a very important role in the induction of peripheral tolerance. However, none of the studies performed so far has shown a complete deletion of ASTC, a small population always persisting in the periphery....
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1996
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192552/ https://www.ncbi.nlm.nih.gov/pubmed/8642317 |
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collection | PubMed |
description | Clonal deletion via activation-induced apoptosis (AIA) of antigen- specific T cells (ASTC) plays a very important role in the induction of peripheral tolerance. However, none of the studies performed so far has shown a complete deletion of ASTC, a small population always persisting in the periphery. The mechanism by which this small population of ASTC escapes AIA has not been determined. Since the existence of these ASTC may influence the outcome of autoimmune diseases and long-term graft survival, we have characterized the properties of these residual ASTC in vivo with the objective of determining mechanisms that may contribute to their persistence. It was found that the resistance of the residual ASTC to AIA is not due to lack of activation or Fas/Fas-L expression. Compared to those susceptible to AIA, the residual ASTC express a high level of Th2-type cytokines that may help them to escape from AIA. Furthermore, they are able to suppress proliferation of other ASTC, suggesting they may, in fact, prolong tolerance in vivo. |
format | Text |
id | pubmed-2192552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21925522008-04-16 Characterization of apoptosis-resistant antigen-specific T cells in vivo J Exp Med Articles Clonal deletion via activation-induced apoptosis (AIA) of antigen- specific T cells (ASTC) plays a very important role in the induction of peripheral tolerance. However, none of the studies performed so far has shown a complete deletion of ASTC, a small population always persisting in the periphery. The mechanism by which this small population of ASTC escapes AIA has not been determined. Since the existence of these ASTC may influence the outcome of autoimmune diseases and long-term graft survival, we have characterized the properties of these residual ASTC in vivo with the objective of determining mechanisms that may contribute to their persistence. It was found that the resistance of the residual ASTC to AIA is not due to lack of activation or Fas/Fas-L expression. Compared to those susceptible to AIA, the residual ASTC express a high level of Th2-type cytokines that may help them to escape from AIA. Furthermore, they are able to suppress proliferation of other ASTC, suggesting they may, in fact, prolong tolerance in vivo. The Rockefeller University Press 1996-05-01 /pmc/articles/PMC2192552/ /pubmed/8642317 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Characterization of apoptosis-resistant antigen-specific T cells in vivo |
title | Characterization of apoptosis-resistant antigen-specific T cells in vivo |
title_full | Characterization of apoptosis-resistant antigen-specific T cells in vivo |
title_fullStr | Characterization of apoptosis-resistant antigen-specific T cells in vivo |
title_full_unstemmed | Characterization of apoptosis-resistant antigen-specific T cells in vivo |
title_short | Characterization of apoptosis-resistant antigen-specific T cells in vivo |
title_sort | characterization of apoptosis-resistant antigen-specific t cells in vivo |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192552/ https://www.ncbi.nlm.nih.gov/pubmed/8642317 |