Cargando…

Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells

The cellular basis of immunological memory has been a debated issue. It is not clear whether CD8 T cell memory is maintained by long-lived cells or by specific or nonspecific restimulation. Here, we have approached the question from a different angle, asking whether the cellular interactions that ar...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192562/
https://www.ncbi.nlm.nih.gov/pubmed/8642325
_version_ 1782147269118656512
collection PubMed
description The cellular basis of immunological memory has been a debated issue. It is not clear whether CD8 T cell memory is maintained by long-lived cells or by specific or nonspecific restimulation. Here, we have approached the question from a different angle, asking whether the cellular interactions that are required to maintain memory are the same as those necessary to activate cytotoxic T lymphocytes. We studied the CD8 memory response to the male antigen H-Y in mice deficient in CD4 cells, or B cells and found that memory in these mice was virtually unimpaired. These results suggest that CD8 memory is CD4 independent and that there is no requirement for long term retention of immune complexes on follicular dendritic cells, nor for B cells as antigen- presenting cells.
format Text
id pubmed-2192562
institution National Center for Biotechnology Information
language English
publishDate 1996
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21925622008-04-16 Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells J Exp Med Articles The cellular basis of immunological memory has been a debated issue. It is not clear whether CD8 T cell memory is maintained by long-lived cells or by specific or nonspecific restimulation. Here, we have approached the question from a different angle, asking whether the cellular interactions that are required to maintain memory are the same as those necessary to activate cytotoxic T lymphocytes. We studied the CD8 memory response to the male antigen H-Y in mice deficient in CD4 cells, or B cells and found that memory in these mice was virtually unimpaired. These results suggest that CD8 memory is CD4 independent and that there is no requirement for long term retention of immune complexes on follicular dendritic cells, nor for B cells as antigen- presenting cells. The Rockefeller University Press 1996-05-01 /pmc/articles/PMC2192562/ /pubmed/8642325 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells
title Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells
title_full Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells
title_fullStr Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells
title_full_unstemmed Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells
title_short Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells
title_sort long-lasting cd8 t cell memory in the absence of cd4 t cells or b cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192562/
https://www.ncbi.nlm.nih.gov/pubmed/8642325