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Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells
The cellular basis of immunological memory has been a debated issue. It is not clear whether CD8 T cell memory is maintained by long-lived cells or by specific or nonspecific restimulation. Here, we have approached the question from a different angle, asking whether the cellular interactions that ar...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1996
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192562/ https://www.ncbi.nlm.nih.gov/pubmed/8642325 |
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collection | PubMed |
description | The cellular basis of immunological memory has been a debated issue. It is not clear whether CD8 T cell memory is maintained by long-lived cells or by specific or nonspecific restimulation. Here, we have approached the question from a different angle, asking whether the cellular interactions that are required to maintain memory are the same as those necessary to activate cytotoxic T lymphocytes. We studied the CD8 memory response to the male antigen H-Y in mice deficient in CD4 cells, or B cells and found that memory in these mice was virtually unimpaired. These results suggest that CD8 memory is CD4 independent and that there is no requirement for long term retention of immune complexes on follicular dendritic cells, nor for B cells as antigen- presenting cells. |
format | Text |
id | pubmed-2192562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21925622008-04-16 Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells J Exp Med Articles The cellular basis of immunological memory has been a debated issue. It is not clear whether CD8 T cell memory is maintained by long-lived cells or by specific or nonspecific restimulation. Here, we have approached the question from a different angle, asking whether the cellular interactions that are required to maintain memory are the same as those necessary to activate cytotoxic T lymphocytes. We studied the CD8 memory response to the male antigen H-Y in mice deficient in CD4 cells, or B cells and found that memory in these mice was virtually unimpaired. These results suggest that CD8 memory is CD4 independent and that there is no requirement for long term retention of immune complexes on follicular dendritic cells, nor for B cells as antigen- presenting cells. The Rockefeller University Press 1996-05-01 /pmc/articles/PMC2192562/ /pubmed/8642325 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells |
title | Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells |
title_full | Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells |
title_fullStr | Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells |
title_full_unstemmed | Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells |
title_short | Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells |
title_sort | long-lasting cd8 t cell memory in the absence of cd4 t cells or b cells |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192562/ https://www.ncbi.nlm.nih.gov/pubmed/8642325 |