Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells

Mice that lack a functional gamma c subunit of the receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 display profound defects in lymphoid development. The IL-7/IL-7R system represents a critical interaction for conventional T and B cell development. In this report, the role of IL-7R alph...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1996
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192680/
https://www.ncbi.nlm.nih.gov/pubmed/8691145
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collection PubMed
description Mice that lack a functional gamma c subunit of the receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 display profound defects in lymphoid development. The IL-7/IL-7R system represents a critical interaction for conventional T and B cell development. In this report, the role of IL-7R alpha in the development of lymphoid lineages other than conventional T and B cells was examined. We demonstrate that gamma delta + T cells were absent in IL-7R alpha-deficient mice, whereas the development and function of natural killer cells were normal. Thus, IL-7R alpha function is required for the development of gamma delta + T cells but not natural killer cells.
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spelling pubmed-21926802008-04-16 Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells J Exp Med Articles Mice that lack a functional gamma c subunit of the receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 display profound defects in lymphoid development. The IL-7/IL-7R system represents a critical interaction for conventional T and B cell development. In this report, the role of IL-7R alpha in the development of lymphoid lineages other than conventional T and B cells was examined. We demonstrate that gamma delta + T cells were absent in IL-7R alpha-deficient mice, whereas the development and function of natural killer cells were normal. Thus, IL-7R alpha function is required for the development of gamma delta + T cells but not natural killer cells. The Rockefeller University Press 1996-07-01 /pmc/articles/PMC2192680/ /pubmed/8691145 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells
title Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells
title_full Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells
title_fullStr Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells
title_full_unstemmed Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells
title_short Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells
title_sort interleukin-7 receptor alpha is essential for the development of gamma delta + t cells, but not natural killer cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192680/
https://www.ncbi.nlm.nih.gov/pubmed/8691145

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