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Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake
Professional antigen-presenting cells, such as macrophages, dendritic cells, or B cells, take up soluble, exogenous antigens (Ags) and process them through the class II pathway. Several reports have shown that phagocytic macrophages also process particulate or soluble forms of exogenous Ag via the c...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1996
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192767/ https://www.ncbi.nlm.nih.gov/pubmed/9064336 |
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collection | PubMed |
description | Professional antigen-presenting cells, such as macrophages, dendritic cells, or B cells, take up soluble, exogenous antigens (Ags) and process them through the class II pathway. Several reports have shown that phagocytic macrophages also process particulate or soluble forms of exogenous Ag via the class I pathway. By contrast, B cells normally do not process soluble, exogenous Ag by way of the class I pathway unless Ags are directly introduced into the cytoplasm. Here we report that B cells present exogenous Ag via the class I pathway when Ags are taken up by receptor-mediated endocytosis. Thus, specialized methods of Ag uptake such as phagocytosis or receptor-mediated endocytosis deliver exogenous Ag into the class I pathway of Ag processing and presentation. |
format | Text |
id | pubmed-2192767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21927672008-04-16 Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake J Exp Med Articles Professional antigen-presenting cells, such as macrophages, dendritic cells, or B cells, take up soluble, exogenous antigens (Ags) and process them through the class II pathway. Several reports have shown that phagocytic macrophages also process particulate or soluble forms of exogenous Ag via the class I pathway. By contrast, B cells normally do not process soluble, exogenous Ag by way of the class I pathway unless Ags are directly introduced into the cytoplasm. Here we report that B cells present exogenous Ag via the class I pathway when Ags are taken up by receptor-mediated endocytosis. Thus, specialized methods of Ag uptake such as phagocytosis or receptor-mediated endocytosis deliver exogenous Ag into the class I pathway of Ag processing and presentation. The Rockefeller University Press 1996-09-01 /pmc/articles/PMC2192767/ /pubmed/9064336 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake |
title | Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake |
title_full | Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake |
title_fullStr | Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake |
title_full_unstemmed | Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake |
title_short | Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake |
title_sort | exogenous antigens gain access to the major histocompatibility complex class i processing pathway in b cells by receptor-mediated uptake |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192767/ https://www.ncbi.nlm.nih.gov/pubmed/9064336 |