T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1

After immunization, activated splenic T cells proliferate in periarteriolar lymphoid sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter nascent germinal centers. Analysis of TCR V(D)J gene rearrangements indicates extensive emigration, frequently involving more than a...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1996
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192770/
https://www.ncbi.nlm.nih.gov/pubmed/9064325
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description After immunization, activated splenic T cells proliferate in periarteriolar lymphoid sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter nascent germinal centers. Analysis of TCR V(D)J gene rearrangements indicates extensive emigration, frequently involving more than a single white pulp region. These migrants constitute a unique set of T helper cells that express antigen- specific alpha beta TCR, CD3, and CD4, but little or no Thy-1, a differentiation antigen present on the great majority of peripheral murine T lymphocytes. The origin of CD4+ Thy-1 follicular T cells appears to be the Thy+ population in the PALS, as both sets commonly share identical V(D)J rearrangements.
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spelling pubmed-21927702008-04-16 T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1 J Exp Med Articles After immunization, activated splenic T cells proliferate in periarteriolar lymphoid sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter nascent germinal centers. Analysis of TCR V(D)J gene rearrangements indicates extensive emigration, frequently involving more than a single white pulp region. These migrants constitute a unique set of T helper cells that express antigen- specific alpha beta TCR, CD3, and CD4, but little or no Thy-1, a differentiation antigen present on the great majority of peripheral murine T lymphocytes. The origin of CD4+ Thy-1 follicular T cells appears to be the Thy+ population in the PALS, as both sets commonly share identical V(D)J rearrangements. The Rockefeller University Press 1996-09-01 /pmc/articles/PMC2192770/ /pubmed/9064325 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1
title T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1
title_full T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1
title_fullStr T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1
title_full_unstemmed T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1
title_short T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1
title_sort t helper cells in murine germinal centers are antigen-specific emigrants that downregulate thy-1
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192770/
https://www.ncbi.nlm.nih.gov/pubmed/9064325

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