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Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage

T cells bearing the class II-restricted, DO-T cell receptor (TCR) are CD4+ if their thymocyte precursors are positively selected on the class II protein, IAd, but they are almost all CD4- after positive selection on a class II for which they have higher avidity, IAb. DO-TCR+ T cells mature in H-2b m...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192895/
https://www.ncbi.nlm.nih.gov/pubmed/8920852
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collection PubMed
description T cells bearing the class II-restricted, DO-T cell receptor (TCR) are CD4+ if their thymocyte precursors are positively selected on the class II protein, IAd, but they are almost all CD4- after positive selection on a class II for which they have higher avidity, IAb. DO-TCR+ T cells mature in H-2b mice lacking CD4. CD4- DO-TCR+ T cells appear in H-2b mice at the same rate as their CD4+ counterparts appear in H-2d animals, suggesting that the CD4- cells are not the product of some minor pathway of thymocyte development and selection. In H-2b CD4 knock out mice expressing human CD2 under the control of the mouse CD4 promoter, mature DO-TCR+ cells did not express human CD2. These results suggest that the CD4-CD8-, DO-TCR+ mature T cells have developed without ever passing through the equivalent of a CD4+,CD8+ stage. The early expression of alpha/beta receptors (TCRs) on thymocytes in TCR transgenic mice may allow maturation of this type. Passage through the equivalent of the CD4+ CD8+, double-positive stage is not essential for differentiation of thymocytes into mature T cells.
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spelling pubmed-21928952008-04-16 Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage J Exp Med Articles T cells bearing the class II-restricted, DO-T cell receptor (TCR) are CD4+ if their thymocyte precursors are positively selected on the class II protein, IAd, but they are almost all CD4- after positive selection on a class II for which they have higher avidity, IAb. DO-TCR+ T cells mature in H-2b mice lacking CD4. CD4- DO-TCR+ T cells appear in H-2b mice at the same rate as their CD4+ counterparts appear in H-2d animals, suggesting that the CD4- cells are not the product of some minor pathway of thymocyte development and selection. In H-2b CD4 knock out mice expressing human CD2 under the control of the mouse CD4 promoter, mature DO-TCR+ cells did not express human CD2. These results suggest that the CD4-CD8-, DO-TCR+ mature T cells have developed without ever passing through the equivalent of a CD4+,CD8+ stage. The early expression of alpha/beta receptors (TCRs) on thymocytes in TCR transgenic mice may allow maturation of this type. Passage through the equivalent of the CD4+ CD8+, double-positive stage is not essential for differentiation of thymocytes into mature T cells. The Rockefeller University Press 1996-11-01 /pmc/articles/PMC2192895/ /pubmed/8920852 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage
title Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage
title_full Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage
title_fullStr Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage
title_full_unstemmed Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage
title_short Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage
title_sort thymocytes can become mature t cells without passing through the cd4+ cd8+, double-positive stage
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192895/
https://www.ncbi.nlm.nih.gov/pubmed/8920852