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Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage
T cells bearing the class II-restricted, DO-T cell receptor (TCR) are CD4+ if their thymocyte precursors are positively selected on the class II protein, IAd, but they are almost all CD4- after positive selection on a class II for which they have higher avidity, IAb. DO-TCR+ T cells mature in H-2b m...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1996
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192895/ https://www.ncbi.nlm.nih.gov/pubmed/8920852 |
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collection | PubMed |
description | T cells bearing the class II-restricted, DO-T cell receptor (TCR) are CD4+ if their thymocyte precursors are positively selected on the class II protein, IAd, but they are almost all CD4- after positive selection on a class II for which they have higher avidity, IAb. DO-TCR+ T cells mature in H-2b mice lacking CD4. CD4- DO-TCR+ T cells appear in H-2b mice at the same rate as their CD4+ counterparts appear in H-2d animals, suggesting that the CD4- cells are not the product of some minor pathway of thymocyte development and selection. In H-2b CD4 knock out mice expressing human CD2 under the control of the mouse CD4 promoter, mature DO-TCR+ cells did not express human CD2. These results suggest that the CD4-CD8-, DO-TCR+ mature T cells have developed without ever passing through the equivalent of a CD4+,CD8+ stage. The early expression of alpha/beta receptors (TCRs) on thymocytes in TCR transgenic mice may allow maturation of this type. Passage through the equivalent of the CD4+ CD8+, double-positive stage is not essential for differentiation of thymocytes into mature T cells. |
format | Text |
id | pubmed-2192895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21928952008-04-16 Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage J Exp Med Articles T cells bearing the class II-restricted, DO-T cell receptor (TCR) are CD4+ if their thymocyte precursors are positively selected on the class II protein, IAd, but they are almost all CD4- after positive selection on a class II for which they have higher avidity, IAb. DO-TCR+ T cells mature in H-2b mice lacking CD4. CD4- DO-TCR+ T cells appear in H-2b mice at the same rate as their CD4+ counterparts appear in H-2d animals, suggesting that the CD4- cells are not the product of some minor pathway of thymocyte development and selection. In H-2b CD4 knock out mice expressing human CD2 under the control of the mouse CD4 promoter, mature DO-TCR+ cells did not express human CD2. These results suggest that the CD4-CD8-, DO-TCR+ mature T cells have developed without ever passing through the equivalent of a CD4+,CD8+ stage. The early expression of alpha/beta receptors (TCRs) on thymocytes in TCR transgenic mice may allow maturation of this type. Passage through the equivalent of the CD4+ CD8+, double-positive stage is not essential for differentiation of thymocytes into mature T cells. The Rockefeller University Press 1996-11-01 /pmc/articles/PMC2192895/ /pubmed/8920852 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage |
title | Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage |
title_full | Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage |
title_fullStr | Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage |
title_full_unstemmed | Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage |
title_short | Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage |
title_sort | thymocytes can become mature t cells without passing through the cd4+ cd8+, double-positive stage |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192895/ https://www.ncbi.nlm.nih.gov/pubmed/8920852 |