Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemia–derived Mutation in the G-CSF Receptor Gene

In approximately 20% of cases of severe congenital neutropenia (SCN), mutations are found in the gene encoding the granulocyte colony-stimulating factor receptor (G-CSF–R). These mutations introduce premature stop codons, which result in truncation of 82–98 COOH-terminal amino acids of the receptor....

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Detalles Bibliográficos
Autores principales: Hermans, Mirjam H.A., Antonissen, Claudia, Ward, Alister C., Mayen, Angelique E.M., Ploemacher, Rob E., Touw, Ivo P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192935/
https://www.ncbi.nlm.nih.gov/pubmed/9989983

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