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Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA
The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or for conserved patterns characteristic of infectious agents. Here we show that human DCs are activated by infl...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192946/ https://www.ncbi.nlm.nih.gov/pubmed/10049946 |
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author | Cella, Marina Salio, Mariolina Sakakibara, Yoichi Langen, Hanno Julkunen, Ilkka Lanzavecchia, Antonio |
author_facet | Cella, Marina Salio, Mariolina Sakakibara, Yoichi Langen, Hanno Julkunen, Ilkka Lanzavecchia, Antonio |
author_sort | Cella, Marina |
collection | PubMed |
description | The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or for conserved patterns characteristic of infectious agents. Here we show that human DCs are activated by influenza virus infection and by double-stranded (ds)RNA. This activation results not only in increased antigen presentation and T cell stimulatory capacity, but also in resistance to the cytopathic effect of the virus, mediated by the production of type I interferon, and upregulation of MxA. Because dsRNA stimulates both maturation and resistance, DCs can serve as altruistic antigen-presenting cells capable of sustaining viral antigen production while acquiring the capacity to trigger naive T cells and drive polarized T helper cell type 1 responses. |
format | Text |
id | pubmed-2192946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21929462008-04-16 Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA Cella, Marina Salio, Mariolina Sakakibara, Yoichi Langen, Hanno Julkunen, Ilkka Lanzavecchia, Antonio J Exp Med Articles The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or for conserved patterns characteristic of infectious agents. Here we show that human DCs are activated by influenza virus infection and by double-stranded (ds)RNA. This activation results not only in increased antigen presentation and T cell stimulatory capacity, but also in resistance to the cytopathic effect of the virus, mediated by the production of type I interferon, and upregulation of MxA. Because dsRNA stimulates both maturation and resistance, DCs can serve as altruistic antigen-presenting cells capable of sustaining viral antigen production while acquiring the capacity to trigger naive T cells and drive polarized T helper cell type 1 responses. The Rockefeller University Press 1999-03-01 /pmc/articles/PMC2192946/ /pubmed/10049946 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Cella, Marina Salio, Mariolina Sakakibara, Yoichi Langen, Hanno Julkunen, Ilkka Lanzavecchia, Antonio Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA |
title | Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA |
title_full | Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA |
title_fullStr | Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA |
title_full_unstemmed | Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA |
title_short | Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA |
title_sort | maturation, activation, and protection of dendritic cells induced by double-stranded rna |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192946/ https://www.ncbi.nlm.nih.gov/pubmed/10049946 |
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