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Targeted Disruption of Migration Inhibitory Factor Gene Reveals Its Critical Role in Sepsis

To study the biologic role of migration inhibitory factor (MIF), a pleiotropic cytokine, we generated a mouse strain lacking MIF by gene targeting in embryonic stem cells. Analysis of the role of MIF during sepsis showed that MIF(−/−) mice were resistant to the lethal effects of high dose bacterial...

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Detalles Bibliográficos
Autores principales:	Bozza, Marcelo, Satoskar, Abhay R., Lin, Guosheng, Lu, Bao, Humbles, Alison A., Gerard, Craig, David, John R.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1999
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192995/ https://www.ncbi.nlm.nih.gov/pubmed/9892616

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