Cargando…

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Can Regulate Dendritic Cell–induced Activation and Cytotoxicity of CD8(+) T Cells Independently of CD4(+)T Cell Help

The mechanisms that regulate the strength and duration of CD8(+) cytotoxic T cell activity determine the effectiveness of an antitumor immune response. To better understand the antitumor effects of anti-cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) antibody treatment, we analyzed the effect o...

Descripción completa

Detalles Bibliográficos
Autores principales:	McCoy, Kathy D., Hermans, Ian F., Henry Fraser, J., Le Gros, Graham, Ronchese, Franca
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1999
Materias:	Brief Definitive Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193004/ https://www.ncbi.nlm.nih.gov/pubmed/10190907

Ejemplares similares

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28
por: Lin, Hua, et al.
Publicado: (1998)

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes
por: Lühder, Fred, et al.
Publicado: (1998)

Immunologic Self-Tolerance Maintained by Cd25(+)Cd4(+)Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
por: Takahashi, Takeshi, et al.
Publicado: (2000)

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25(+)Cd4(+) Regulatory Cells That Control Intestinal Inflammation
por: Read, Simon, et al.
Publicado: (2000)

Cytotoxic T Lymphocyte Antigen 4 and CD28 Modulate Cell Surface Raft Expression in Their Regulation of T Cell Function
por: Martin, Margarita, et al.
Publicado: (2001)

B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28
por: Fallarino, Francesca, et al.
Publicado: (1998)

Human Dendritic Cells Activated by TSLP and CD40L Induce Proallergic Cytotoxic T Cells
por: Gilliet, Michel, et al.
Publicado: (2003)

Immature Dendritic Cells Acquire Cd8(+)Cytotoxic T Lymphocyte Priming Capacity upon Activation by T Helper Cell–Independent or–Dependent Stimuli
por: Schuurhuis, Danita H., et al.
Publicado: (2000)

B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)
por: Mandelbrot, Didier A., et al.
Publicado: (1999)

Role of CD8 in Aberrant Function of Cytotoxic T Lymphocytes
por: Kessler, Benedikt, et al.
Publicado: (1997)

CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4(+) T cells
por: Hao, Yuwei, et al.
Publicado: (2023)

Murine CD4(+) T Cell Responses Are Inhibited by Cytotoxic T Cell-Mediated Killing of Dendritic Cells and Are Restored by Antigen Transfer
por: Ma, Joel Zhi-Iong, et al.
Publicado: (2012)

In Vivo Cytotoxic T Lymphocyte Elicitation by Mycobacterial Heat Shock Protein 70 Fusion Proteins Maps to a Discrete Domain and Is Cd4(+) T Cell Independent
por: Huang, Qian, et al.
Publicado: (2000)

Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade
por: McCoy, Kathy, et al.
Publicado: (1997)

Regulatory T cells inhibit stable contacts between CD4(+) T cells and dendritic cells in vivo
por: Tadokoro, Carlos E., et al.
Publicado: (2006)

Induction of a CD8(+) Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4(+) T Cell Help
por: Bennett, Sally R.M., et al.
Publicado: (1997)

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses
por: Kalams, Spyros A., et al.
Publicado: (1998)

Negative Regulation of T Cell Receptor–Lipid Raft Interaction by Cytotoxic T Lymphocyte–associated Antigen 4
por: Chikuma, Shunsuke, et al.
Publicado: (2003)

Melanoma Cells Present a MAGE-3 Epitope to CD4(+) Cytotoxic T Cells in Association with Histocompatibility Leukocyte Antigen DR11
por: Manici, Simona, et al.
Publicado: (1999)

CD39(+) conventional CD4(+) T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade
por: Bossio, Sabrina N., et al.
Publicado: (2023)

Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells
por: Doyle, Alden M., et al.
Publicado: (2001)

CD4(+) T Cell Help Impairs CD8(+) T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity
por: Kurts, Christian, et al.
Publicado: (1997)

NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4(+) T lymphocytes by CD4(+) CD25(+) regulatory T cells
por: Bopp, Tobias, et al.
Publicado: (2005)

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4(+) T Cells
por: Chen, Wanjun, et al.
Publicado: (1998)

The Era of Cytotoxic CD4 T Cells
por: Cenerenti, Mara, et al.
Publicado: (2022)

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies
por: Peggs, Karl S., et al.
Publicado: (2009)

Conditions for the generation of cytotoxic CD4(+) Th cells that enhance CD8(+) CTL-mediated tumor regression
por: Li, Kunyu, et al.
Publicado: (2016)

Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo
por: Lee, Delphine J., et al.
Publicado: (1998)

Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells
Publicado: (1987)

Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) Signaling in T-Cell Biology and Disease Therapy
por: Kim, Gil-Ran, et al.
Publicado: (2022)

CTLA-4 blockade during dendritic cell based booster vaccination influences dendritic cell survival and CTL expansion
por: Pedersen, Anders E, et al.
Publicado: (2007)

Cd40-Independent Pathways of T Cell Help for Priming of Cd8(+) Cytotoxic T Lymphocytes
por: Lu, Zhengbin, et al.
Publicado: (2000)

CRTAM determines the CD4(+) cytotoxic T lymphocyte lineage
por: Takeuchi, Arata, et al.
Publicado: (2016)

Cytotoxic CD4 T Cells in Antiviral Immunity
por: Marshall, Nikki B., et al.
Publicado: (2011)

Cytotoxic CD4 T cells in the mucosa and in cancer
por: Venkatesh, Hrishi, et al.
Publicado: (2023)

Cooperative Roles of CTLA-4 and Regulatory T Cells in Tolerance to an Islet Cell Antigen
por: Eggena, Mark P., et al.
Publicado: (2004)

Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4(+)CD8A(+) T cells related to mouse CD4 cytotoxic T cells
por: Tanemoto, Shun, et al.
Publicado: (2022)

CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation
por: Lingel, Holger, et al.
Publicado: (2017)

Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) suppresses Staphylococcus aureus-induced CD80, CD86, and pro-inflammatory cytokine expression in human B cells
por: Liu, Po-Chun, et al.
Publicado: (2020)

Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells
por: Dalton, Dyana K., et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_7pdullq1dp4jfqf32asidjs8rg