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Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis

Molecular mimicry refers to structural homologies between a self-protein and a microbial protein. A major epitope of myelin basic protein (MBP), p87–99 (VHFFKNIVTPRTP), induces experimental autoimmune encephalomyelitis (EAE). VHFFK contains the major residues for binding of this self-molecule to T c...

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Autores principales: Ruiz, Pedro J., Garren, Hideki, Hirschberg, David L., Langer-Gould, Annette M., Levite, Mia, Karpuj, Marcela V., Southwood, Scott, Sette, Alessandro, Conlon, Paul, Steinman, Lawrence
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193020/
https://www.ncbi.nlm.nih.gov/pubmed/10209044
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author Ruiz, Pedro J.
Garren, Hideki
Hirschberg, David L.
Langer-Gould, Annette M.
Levite, Mia
Karpuj, Marcela V.
Southwood, Scott
Sette, Alessandro
Conlon, Paul
Steinman, Lawrence
author_facet Ruiz, Pedro J.
Garren, Hideki
Hirschberg, David L.
Langer-Gould, Annette M.
Levite, Mia
Karpuj, Marcela V.
Southwood, Scott
Sette, Alessandro
Conlon, Paul
Steinman, Lawrence
author_sort Ruiz, Pedro J.
collection PubMed
description Molecular mimicry refers to structural homologies between a self-protein and a microbial protein. A major epitope of myelin basic protein (MBP), p87–99 (VHFFKNIVTPRTP), induces experimental autoimmune encephalomyelitis (EAE). VHFFK contains the major residues for binding of this self-molecule to T cell receptor (TCR) and to the major histocompatibility complex. Peptides from papilloma virus strains containing the motif VHFFK induce EAE. A peptide from human papilloma virus type 40 (HPV 40) containing VHFFR, and one from HPV 32 containing VHFFH, prevented EAE. A sequence from Bacillus subtilis (RKVVTDFFKNIPQRI) also prevented EAE. T cell lines, producing IL-4 and specific for these microbial peptides, suppressed EAE. Thus, microbial peptides, differing from the core motif of the self-antigen, MBPp87–99, function as altered peptide ligands, and behave as TCR antagonists, in the modulation of autoimmune disease.
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spelling pubmed-21930202008-04-16 Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis Ruiz, Pedro J. Garren, Hideki Hirschberg, David L. Langer-Gould, Annette M. Levite, Mia Karpuj, Marcela V. Southwood, Scott Sette, Alessandro Conlon, Paul Steinman, Lawrence J Exp Med Articles Molecular mimicry refers to structural homologies between a self-protein and a microbial protein. A major epitope of myelin basic protein (MBP), p87–99 (VHFFKNIVTPRTP), induces experimental autoimmune encephalomyelitis (EAE). VHFFK contains the major residues for binding of this self-molecule to T cell receptor (TCR) and to the major histocompatibility complex. Peptides from papilloma virus strains containing the motif VHFFK induce EAE. A peptide from human papilloma virus type 40 (HPV 40) containing VHFFR, and one from HPV 32 containing VHFFH, prevented EAE. A sequence from Bacillus subtilis (RKVVTDFFKNIPQRI) also prevented EAE. T cell lines, producing IL-4 and specific for these microbial peptides, suppressed EAE. Thus, microbial peptides, differing from the core motif of the self-antigen, MBPp87–99, function as altered peptide ligands, and behave as TCR antagonists, in the modulation of autoimmune disease. The Rockefeller University Press 1999-04-19 /pmc/articles/PMC2193020/ /pubmed/10209044 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Ruiz, Pedro J.
Garren, Hideki
Hirschberg, David L.
Langer-Gould, Annette M.
Levite, Mia
Karpuj, Marcela V.
Southwood, Scott
Sette, Alessandro
Conlon, Paul
Steinman, Lawrence
Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis
title Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis
title_full Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis
title_fullStr Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis
title_full_unstemmed Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis
title_short Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis
title_sort microbial epitopes act as altered peptide ligands to prevent experimental autoimmune encephalomyelitis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193020/
https://www.ncbi.nlm.nih.gov/pubmed/10209044
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