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Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis
Molecular mimicry refers to structural homologies between a self-protein and a microbial protein. A major epitope of myelin basic protein (MBP), p87–99 (VHFFKNIVTPRTP), induces experimental autoimmune encephalomyelitis (EAE). VHFFK contains the major residues for binding of this self-molecule to T c...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193020/ https://www.ncbi.nlm.nih.gov/pubmed/10209044 |
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author | Ruiz, Pedro J. Garren, Hideki Hirschberg, David L. Langer-Gould, Annette M. Levite, Mia Karpuj, Marcela V. Southwood, Scott Sette, Alessandro Conlon, Paul Steinman, Lawrence |
author_facet | Ruiz, Pedro J. Garren, Hideki Hirschberg, David L. Langer-Gould, Annette M. Levite, Mia Karpuj, Marcela V. Southwood, Scott Sette, Alessandro Conlon, Paul Steinman, Lawrence |
author_sort | Ruiz, Pedro J. |
collection | PubMed |
description | Molecular mimicry refers to structural homologies between a self-protein and a microbial protein. A major epitope of myelin basic protein (MBP), p87–99 (VHFFKNIVTPRTP), induces experimental autoimmune encephalomyelitis (EAE). VHFFK contains the major residues for binding of this self-molecule to T cell receptor (TCR) and to the major histocompatibility complex. Peptides from papilloma virus strains containing the motif VHFFK induce EAE. A peptide from human papilloma virus type 40 (HPV 40) containing VHFFR, and one from HPV 32 containing VHFFH, prevented EAE. A sequence from Bacillus subtilis (RKVVTDFFKNIPQRI) also prevented EAE. T cell lines, producing IL-4 and specific for these microbial peptides, suppressed EAE. Thus, microbial peptides, differing from the core motif of the self-antigen, MBPp87–99, function as altered peptide ligands, and behave as TCR antagonists, in the modulation of autoimmune disease. |
format | Text |
id | pubmed-2193020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21930202008-04-16 Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis Ruiz, Pedro J. Garren, Hideki Hirschberg, David L. Langer-Gould, Annette M. Levite, Mia Karpuj, Marcela V. Southwood, Scott Sette, Alessandro Conlon, Paul Steinman, Lawrence J Exp Med Articles Molecular mimicry refers to structural homologies between a self-protein and a microbial protein. A major epitope of myelin basic protein (MBP), p87–99 (VHFFKNIVTPRTP), induces experimental autoimmune encephalomyelitis (EAE). VHFFK contains the major residues for binding of this self-molecule to T cell receptor (TCR) and to the major histocompatibility complex. Peptides from papilloma virus strains containing the motif VHFFK induce EAE. A peptide from human papilloma virus type 40 (HPV 40) containing VHFFR, and one from HPV 32 containing VHFFH, prevented EAE. A sequence from Bacillus subtilis (RKVVTDFFKNIPQRI) also prevented EAE. T cell lines, producing IL-4 and specific for these microbial peptides, suppressed EAE. Thus, microbial peptides, differing from the core motif of the self-antigen, MBPp87–99, function as altered peptide ligands, and behave as TCR antagonists, in the modulation of autoimmune disease. The Rockefeller University Press 1999-04-19 /pmc/articles/PMC2193020/ /pubmed/10209044 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Ruiz, Pedro J. Garren, Hideki Hirschberg, David L. Langer-Gould, Annette M. Levite, Mia Karpuj, Marcela V. Southwood, Scott Sette, Alessandro Conlon, Paul Steinman, Lawrence Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis |
title | Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis |
title_full | Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis |
title_fullStr | Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis |
title_full_unstemmed | Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis |
title_short | Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis |
title_sort | microbial epitopes act as altered peptide ligands to prevent experimental autoimmune encephalomyelitis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193020/ https://www.ncbi.nlm.nih.gov/pubmed/10209044 |
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