Signal Transducer and Activator of  Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis

Signal transducer and activator of transcription (STAT)5 is constitutively activated in BCR/ ABL-expressing cells, but the mechanisms and functional consequences of such activation are unknown. We show here that BCR/ABL induces phosphorylation and activation of STAT5 by a mechanism that requires the...

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Detalles Bibliográficos
Autores principales: Nieborowska-Skorska, Malgorzata, Wasik, Mariusz A., Slupianek, Artur, Salomoni, Paolo, Kitamura, Toshio, Calabretta, Bruno, Skorski, Tomasz
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193033/
https://www.ncbi.nlm.nih.gov/pubmed/10209040

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