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Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation

Epidemiologic investigations have shown that exercise reduces morbidity and mortality from coronary artery disease. In this study, using a rat model, we attempted to determine whether exercise can reduce ischemic injury to the heart and elucidate a mechanism for the cardioprotective effect of exerci...

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Autores principales: Yamashita, Nobushige, Hoshida, Shiro, Otsu, Kinya, Asahi, Michio, Kuzuya, Tsunehiko, Hori, Masatsugu
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193084/
https://www.ncbi.nlm.nih.gov/pubmed/10359573
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author Yamashita, Nobushige
Hoshida, Shiro
Otsu, Kinya
Asahi, Michio
Kuzuya, Tsunehiko
Hori, Masatsugu
author_facet Yamashita, Nobushige
Hoshida, Shiro
Otsu, Kinya
Asahi, Michio
Kuzuya, Tsunehiko
Hori, Masatsugu
author_sort Yamashita, Nobushige
collection PubMed
description Epidemiologic investigations have shown that exercise reduces morbidity and mortality from coronary artery disease. In this study, using a rat model, we attempted to determine whether exercise can reduce ischemic injury to the heart and elucidate a mechanism for the cardioprotective effect of exercise. Results showed that exercise significantly reduced the magnitude of a myocardial infarction in biphasic manner. The time course for cardioprotection resembled that of the change in manganese superoxide dismutase (Mn-SOD) activity. The administration of the antisense oligodeoxyribonucleotide to Mn-SOD abolished the expected decrease in infarct size. We showed that the level of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) increased after exercise. The simultaneous administration of the neutralizing antibodies to the cytokines abolished the exercise-induced cardioprotection and the activation of Mn-SOD. Furthermore, TNF-α can mimic the biphasic pattern of cardioprotection and activation of Mn-SOD. An antioxidant completely abolished cardioprotection and the activation of Mn-SOD by exercise or the injection of TNF-α as well as exercise-induced increase in TNF-α and IL-1β. The production of reactive oxygen species and endogenous TNF-α and IL-1β induced by exercise leads to the activation of Mn-SOD, which plays major roles in the acquisition of biphasic cardioprotection against ischemia/reperfusion injury in rats.
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spelling pubmed-21930842008-04-16 Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation Yamashita, Nobushige Hoshida, Shiro Otsu, Kinya Asahi, Michio Kuzuya, Tsunehiko Hori, Masatsugu J Exp Med Articles Epidemiologic investigations have shown that exercise reduces morbidity and mortality from coronary artery disease. In this study, using a rat model, we attempted to determine whether exercise can reduce ischemic injury to the heart and elucidate a mechanism for the cardioprotective effect of exercise. Results showed that exercise significantly reduced the magnitude of a myocardial infarction in biphasic manner. The time course for cardioprotection resembled that of the change in manganese superoxide dismutase (Mn-SOD) activity. The administration of the antisense oligodeoxyribonucleotide to Mn-SOD abolished the expected decrease in infarct size. We showed that the level of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) increased after exercise. The simultaneous administration of the neutralizing antibodies to the cytokines abolished the exercise-induced cardioprotection and the activation of Mn-SOD. Furthermore, TNF-α can mimic the biphasic pattern of cardioprotection and activation of Mn-SOD. An antioxidant completely abolished cardioprotection and the activation of Mn-SOD by exercise or the injection of TNF-α as well as exercise-induced increase in TNF-α and IL-1β. The production of reactive oxygen species and endogenous TNF-α and IL-1β induced by exercise leads to the activation of Mn-SOD, which plays major roles in the acquisition of biphasic cardioprotection against ischemia/reperfusion injury in rats. The Rockefeller University Press 1999-06-07 /pmc/articles/PMC2193084/ /pubmed/10359573 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Yamashita, Nobushige
Hoshida, Shiro
Otsu, Kinya
Asahi, Michio
Kuzuya, Tsunehiko
Hori, Masatsugu
Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation
title Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation
title_full Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation
title_fullStr Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation
title_full_unstemmed Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation
title_short Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation
title_sort exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193084/
https://www.ncbi.nlm.nih.gov/pubmed/10359573
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