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Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies
Serum immunoglobulin (Ig)M provides the initial response to foreign antigen and plays a regulatory role in subsequent immune response development, accelerating the production of high-affinity IgG. Here we show that mice deficient in serum IgM have an increased propensity to spontaneous autoimmunity...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193170/ https://www.ncbi.nlm.nih.gov/pubmed/10748243 |
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author | Ehrenstein, Michael R. Cook, H. Terence Neuberger, Michael S. |
author_facet | Ehrenstein, Michael R. Cook, H. Terence Neuberger, Michael S. |
author_sort | Ehrenstein, Michael R. |
collection | PubMed |
description | Serum immunoglobulin (Ig)M provides the initial response to foreign antigen and plays a regulatory role in subsequent immune response development, accelerating the production of high-affinity IgG. Here we show that mice deficient in serum IgM have an increased propensity to spontaneous autoimmunity as judged by the development with age of serum IgG anti-DNA antibodies and the renal deposition of IgG and complement. They also exhibit augmented anti-DNA IgG production on exposure to lipopolysaccharide. Thus, deficiency in serum IgM leads to diminished responsiveness to foreign antigens but increased responsiveness to self—a paradoxical association reminiscent of that described in humans deficient in complement or IgA. We wondered whether serum IgM might play an analogous role with regard to the response to self-antigens. However, here—in contrast to the sluggish response to foreign antigens—we find that deficiency in serum IgM actually predisposes to the development of IgG antibodies to autoantigens. |
format | Text |
id | pubmed-2193170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21931702008-04-16 Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies Ehrenstein, Michael R. Cook, H. Terence Neuberger, Michael S. J Exp Med Brief Definitive Report Serum immunoglobulin (Ig)M provides the initial response to foreign antigen and plays a regulatory role in subsequent immune response development, accelerating the production of high-affinity IgG. Here we show that mice deficient in serum IgM have an increased propensity to spontaneous autoimmunity as judged by the development with age of serum IgG anti-DNA antibodies and the renal deposition of IgG and complement. They also exhibit augmented anti-DNA IgG production on exposure to lipopolysaccharide. Thus, deficiency in serum IgM leads to diminished responsiveness to foreign antigens but increased responsiveness to self—a paradoxical association reminiscent of that described in humans deficient in complement or IgA. We wondered whether serum IgM might play an analogous role with regard to the response to self-antigens. However, here—in contrast to the sluggish response to foreign antigens—we find that deficiency in serum IgM actually predisposes to the development of IgG antibodies to autoantigens. The Rockefeller University Press 2000-04-03 /pmc/articles/PMC2193170/ /pubmed/10748243 Text en © 2000 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Definitive Report Ehrenstein, Michael R. Cook, H. Terence Neuberger, Michael S. Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies |
title | Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies |
title_full | Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies |
title_fullStr | Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies |
title_full_unstemmed | Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies |
title_short | Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies |
title_sort | deficiency in serum immunoglobulin (ig)m predisposes to development of igg autoantibodies |
topic | Brief Definitive Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193170/ https://www.ncbi.nlm.nih.gov/pubmed/10748243 |
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