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Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies

Serum immunoglobulin (Ig)M provides the initial response to foreign antigen and plays a regulatory role in subsequent immune response development, accelerating the production of high-affinity IgG. Here we show that mice deficient in serum IgM have an increased propensity to spontaneous autoimmunity...

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Detalles Bibliográficos
Autores principales: Ehrenstein, Michael R., Cook, H. Terence, Neuberger, Michael S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193170/
https://www.ncbi.nlm.nih.gov/pubmed/10748243
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author Ehrenstein, Michael R.
Cook, H. Terence
Neuberger, Michael S.
author_facet Ehrenstein, Michael R.
Cook, H. Terence
Neuberger, Michael S.
author_sort Ehrenstein, Michael R.
collection PubMed
description Serum immunoglobulin (Ig)M provides the initial response to foreign antigen and plays a regulatory role in subsequent immune response development, accelerating the production of high-affinity IgG. Here we show that mice deficient in serum IgM have an increased propensity to spontaneous autoimmunity as judged by the development with age of serum IgG anti-DNA antibodies and the renal deposition of IgG and complement. They also exhibit augmented anti-DNA IgG production on exposure to lipopolysaccharide. Thus, deficiency in serum IgM leads to diminished responsiveness to foreign antigens but increased responsiveness to self—a paradoxical association reminiscent of that described in humans deficient in complement or IgA. We wondered whether serum IgM might play an analogous role with regard to the response to self-antigens. However, here—in contrast to the sluggish response to foreign antigens—we find that deficiency in serum IgM actually predisposes to the development of IgG antibodies to autoantigens.
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spelling pubmed-21931702008-04-16 Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies Ehrenstein, Michael R. Cook, H. Terence Neuberger, Michael S. J Exp Med Brief Definitive Report Serum immunoglobulin (Ig)M provides the initial response to foreign antigen and plays a regulatory role in subsequent immune response development, accelerating the production of high-affinity IgG. Here we show that mice deficient in serum IgM have an increased propensity to spontaneous autoimmunity as judged by the development with age of serum IgG anti-DNA antibodies and the renal deposition of IgG and complement. They also exhibit augmented anti-DNA IgG production on exposure to lipopolysaccharide. Thus, deficiency in serum IgM leads to diminished responsiveness to foreign antigens but increased responsiveness to self—a paradoxical association reminiscent of that described in humans deficient in complement or IgA. We wondered whether serum IgM might play an analogous role with regard to the response to self-antigens. However, here—in contrast to the sluggish response to foreign antigens—we find that deficiency in serum IgM actually predisposes to the development of IgG antibodies to autoantigens. The Rockefeller University Press 2000-04-03 /pmc/articles/PMC2193170/ /pubmed/10748243 Text en © 2000 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Report
Ehrenstein, Michael R.
Cook, H. Terence
Neuberger, Michael S.
Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies
title Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies
title_full Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies
title_fullStr Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies
title_full_unstemmed Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies
title_short Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies
title_sort deficiency in serum immunoglobulin (ig)m predisposes to development of igg autoantibodies
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193170/
https://www.ncbi.nlm.nih.gov/pubmed/10748243
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