Somatic Hypermutation in the Absence of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-Pk(cs)) or Recombination-Activating Gene (Rag)1 Activity

Somatic hypermutation and isotype switch recombination occur in germinal center B cells, are linked to transcription, and are similarly affected by deficiency in MutS homologue (MSH)2. Class-switch recombination is abrogated by disruption of genes encoding components of the catalytic subunit of DNA-...

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Detalles Bibliográficos
Autores principales: Bemark, Mats, Sale, Julian E., Kim, Hye-Jung, Berek, Claudia, Cosgrove, Ruth A., Neuberger, Michael S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193187/
https://www.ncbi.nlm.nih.gov/pubmed/11085752

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