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Clonal Expansions of Cd8(+) T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction
Clonal composition and T cell receptor (TCR) repertoire of CD4(+) and CD8(+) T cells infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with unprecedented resolution at the level of single cells. Individual CD4(+) or CD8(+) T cells were isolated from frozen sections...
Autores principales: | Babbe, Holger, Roers, Axel, Waisman, Ari, Lassmann, Hans, Goebels, Norbert, Hohlfeld, Reinhard, Friese, Michael, Schröder, Roland, Deckert, Martina, Schmidt, Stephan, Ravid, Rivka, Rajewsky, Klaus |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193223/ https://www.ncbi.nlm.nih.gov/pubmed/10934227 |
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