X-Linked Lymphoproliferative Disease: 2b4 Molecules Displaying Inhibitory Rather than Activating Function Are Responsible for the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected Cells

2B4 is a surface molecule involved in activation of the natural killer (NK) cell–mediated cytotoxicity. It binds a protein termed Src homology 2 domain–containing protein (SH2D1A) or signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), which in turn has been proposed to function...

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Detalles Bibliográficos
Autores principales: Parolini, Silvia, Bottino, Cristina, Falco, Michela, Augugliaro, Raffaella, Giliani, Silvia, Franceschini, Roberta, Ochs, Hans D., Wolf, Hermann, Bonnefoy, Jean-Yves, Biassoni, Roberto, Moretta, Lorenzo, Notarangelo, Luigi D., Moretta, Alessandro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193227/
https://www.ncbi.nlm.nih.gov/pubmed/10934222

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