Cargando…

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

In a depleted lymphoid compartment, naive T cells begin a slow proliferation that is independent of cognate antigen yet requires recognition of major histocompatibility complex–bound self-peptides. We have followed the phenotypic and functional changes that occur when naive CD8(+) T cells undergo th...

Descripción completa

Detalles Bibliográficos
Autores principales: Goldrath, Ananda W., Bogatzki, Lisa Y., Bevan, Michael J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193243/
https://www.ncbi.nlm.nih.gov/pubmed/10952725
_version_ 1782147424931807232
author Goldrath, Ananda W.
Bogatzki, Lisa Y.
Bevan, Michael J.
author_facet Goldrath, Ananda W.
Bogatzki, Lisa Y.
Bevan, Michael J.
author_sort Goldrath, Ananda W.
collection PubMed
description In a depleted lymphoid compartment, naive T cells begin a slow proliferation that is independent of cognate antigen yet requires recognition of major histocompatibility complex–bound self-peptides. We have followed the phenotypic and functional changes that occur when naive CD8(+) T cells undergo this type of expansion in a lymphopenic environment. Naive T cells undergoing homeostasis-driven proliferation convert to a phenotypic and functional state similar to that of memory T cells, yet distinct from antigen-activated effector T cells. Naive T cells dividing in a lymphopenic host upregulate CD44, CD122 (interleukin 2 receptor β) and Ly6C expression, acquire the ability to rapidly secrete interferon γ, and become cytotoxic effectors when stimulated with cognate antigen. The conversion of naive T cells to cells masquerading as memory cells in response to a homeostatic signal does not represent an irreversible differentiation. Once the cellularity of the lymphoid compartment is restored and the T cells cease their division, they regain the functional and phenotypic characteristics of naive T cells. Thus, homeostasis-driven proliferation provides a thymus-independent mechanism for restoration of the naive compartment after a loss of T cells.
format Text
id pubmed-2193243
institution National Center for Biotechnology Information
language English
publishDate 2000
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21932432008-04-16 Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation Goldrath, Ananda W. Bogatzki, Lisa Y. Bevan, Michael J. J Exp Med Original Article In a depleted lymphoid compartment, naive T cells begin a slow proliferation that is independent of cognate antigen yet requires recognition of major histocompatibility complex–bound self-peptides. We have followed the phenotypic and functional changes that occur when naive CD8(+) T cells undergo this type of expansion in a lymphopenic environment. Naive T cells undergoing homeostasis-driven proliferation convert to a phenotypic and functional state similar to that of memory T cells, yet distinct from antigen-activated effector T cells. Naive T cells dividing in a lymphopenic host upregulate CD44, CD122 (interleukin 2 receptor β) and Ly6C expression, acquire the ability to rapidly secrete interferon γ, and become cytotoxic effectors when stimulated with cognate antigen. The conversion of naive T cells to cells masquerading as memory cells in response to a homeostatic signal does not represent an irreversible differentiation. Once the cellularity of the lymphoid compartment is restored and the T cells cease their division, they regain the functional and phenotypic characteristics of naive T cells. Thus, homeostasis-driven proliferation provides a thymus-independent mechanism for restoration of the naive compartment after a loss of T cells. The Rockefeller University Press 2000-08-21 /pmc/articles/PMC2193243/ /pubmed/10952725 Text en © 2000 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Original Article
Goldrath, Ananda W.
Bogatzki, Lisa Y.
Bevan, Michael J.
Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation
title Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation
title_full Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation
title_fullStr Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation
title_full_unstemmed Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation
title_short Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation
title_sort naive t cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193243/
https://www.ncbi.nlm.nih.gov/pubmed/10952725
work_keys_str_mv AT goldrathanandaw naivetcellstransientlyacquireamemorylikephenotypeduringhomeostasisdrivenproliferation
AT bogatzkilisay naivetcellstransientlyacquireamemorylikephenotypeduringhomeostasisdrivenproliferation
AT bevanmichaelj naivetcellstransientlyacquireamemorylikephenotypeduringhomeostasisdrivenproliferation