Blockade of Transforming Growth Factor β/Smad Signaling in T Cells by Overexpression of Smad7 Enhances Antigen-Induced Airway Inflammation and Airway Reactivity

Transforming growth factor (TGF)-β has been implicated in immunosuppression. However, it remains obscure whether regulation of T cells by TGF-β contributes to the immunosuppression in vivo. To address this issue, we developed transgenic mice expressing Smad7, an intracellular antagonist of TGF-β/Sma...

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Detalles Bibliográficos
Autores principales: Nakao, Atsuhito, Miike, Satoshi, Hatano, Masahiko, Okumura, Ko, Tokuhisa, Takeshi, Ra, Chisei, Iwamoto, Itsuo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193250/
https://www.ncbi.nlm.nih.gov/pubmed/10899902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193250/
https://www.ncbi.nlm.nih.gov/pubmed/10899902

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