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Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity
Innate immune responses to pathogens critically impact the development of adaptive immune responses. However, it is not completely understood how innate immunity controls the initiation of adaptive immunities or how it determines which type of adaptive immunity will be induced to eliminate a given p...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193254/ https://www.ncbi.nlm.nih.gov/pubmed/10899908 |
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author | Kadowaki, Norimitsu Antonenko, Svetlana Lau, Johnson Yiu-Nam Liu, Yong-Jun |
author_facet | Kadowaki, Norimitsu Antonenko, Svetlana Lau, Johnson Yiu-Nam Liu, Yong-Jun |
author_sort | Kadowaki, Norimitsu |
collection | PubMed |
description | Innate immune responses to pathogens critically impact the development of adaptive immune responses. However, it is not completely understood how innate immunity controls the initiation of adaptive immunities or how it determines which type of adaptive immunity will be induced to eliminate a given pathogen. Here we show that viral stimulation not only triggers natural interferon (IFN)-α/β–producing cells (IPCs) to produce vast amounts of antiviral IFN-α/β but also induces these cells to differentiate into dendritic cells (DCs). IFN-α/β and tumor necrosis factor α produced by virus-activated IPCs act as autocrine survival and DC differentiation factors, respectively. The virus-induced DCs stimulate naive CD4(+) T cells to produce IFN-γ and interleukin (IL)-10, in contrast to IL-3–induced DCs, which stimulate naive CD4(+) T cells to produce T helper type 2 cytokines IL-4, IL-5, and IL-10. Thus, IPCs may play two master roles in antiviral immune responses: directly inhibiting viral replication by producing large amounts of IFN-α/β, and subsequently triggering adaptive T cell–mediated immunity by differentiating into DCs. IPCs constitute a critical link between innate and adaptive immunity. |
format | Text |
id | pubmed-2193254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21932542008-04-16 Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity Kadowaki, Norimitsu Antonenko, Svetlana Lau, Johnson Yiu-Nam Liu, Yong-Jun J Exp Med Original Article Innate immune responses to pathogens critically impact the development of adaptive immune responses. However, it is not completely understood how innate immunity controls the initiation of adaptive immunities or how it determines which type of adaptive immunity will be induced to eliminate a given pathogen. Here we show that viral stimulation not only triggers natural interferon (IFN)-α/β–producing cells (IPCs) to produce vast amounts of antiviral IFN-α/β but also induces these cells to differentiate into dendritic cells (DCs). IFN-α/β and tumor necrosis factor α produced by virus-activated IPCs act as autocrine survival and DC differentiation factors, respectively. The virus-induced DCs stimulate naive CD4(+) T cells to produce IFN-γ and interleukin (IL)-10, in contrast to IL-3–induced DCs, which stimulate naive CD4(+) T cells to produce T helper type 2 cytokines IL-4, IL-5, and IL-10. Thus, IPCs may play two master roles in antiviral immune responses: directly inhibiting viral replication by producing large amounts of IFN-α/β, and subsequently triggering adaptive T cell–mediated immunity by differentiating into DCs. IPCs constitute a critical link between innate and adaptive immunity. The Rockefeller University Press 2000-07-17 /pmc/articles/PMC2193254/ /pubmed/10899908 Text en © 2000 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Original Article Kadowaki, Norimitsu Antonenko, Svetlana Lau, Johnson Yiu-Nam Liu, Yong-Jun Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity |
title | Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity |
title_full | Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity |
title_fullStr | Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity |
title_full_unstemmed | Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity |
title_short | Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity |
title_sort | natural interferon α/β–producing cells link innate and adaptive immunity |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193254/ https://www.ncbi.nlm.nih.gov/pubmed/10899908 |
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