Metabolic Consequences of Adenosine Deaminase Deficiency in Mice Are Associated with Defects in Alveogenesis, Pulmonary Inflammation, and Airway Obstruction

Adenosine deaminase (ADA) is a purine catabolic enzyme that manages levels of the biologically active purines adenosine and 2′-deoxyadenosine in tissues and cells. ADA-deficient mice die at 3 wk of age from severe respiratory distress. This phenotype is progressive and is linked to perturbations in...

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Detalles Bibliográficos
Autores principales: Blackburn, Michael R., Volmer, Jonathan B., Thrasher, Janci L., Zhong, Hongyan, Crosby, Jeff R., Lee, James J., Kellems, Rodney E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193256/
https://www.ncbi.nlm.nih.gov/pubmed/10899903

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