Chromatin Remodeling by the T Cell Receptor (Tcr)-β Gene Enhancer during Early T Cell Development: Implications for the Control of Tcr-β Locus Recombination

Gene targeting studies have shown that T cell receptor (TCR)-β gene expression and recombination are inhibited after deletion of an enhancer (Eβ) located at the 3′ end of the ∼500-kb TCR-β locus. Using knockout mouse models, we have measured, at different regions throughout the TCR-β locus, the effe...

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Detalles Bibliográficos
Autores principales: Mathieu, Noëlle, Hempel, William M., Spicuglia, Salvatore, Verthuy, Christophe, Ferrier, Pierre
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193263/
https://www.ncbi.nlm.nih.gov/pubmed/10974029

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