Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection

Tec family kinases are implicated in T cell receptor (TCR) signaling, and combined mutation of inducible T cell kinase (Itk) and resting lymphocyte kinase (Rlk)/Txk in mice dramatically impairs mature T cell function. Nonetheless, mutation of these kinases still permits T cell development. While itk...

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Detalles Bibliográficos
Autores principales: Schaeffer, Edward M., Broussard, Christine, Debnath, Jayanta, Anderson, Stacie, McVicar, Daniel W., Schwartzberg, Pamela L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193319/
https://www.ncbi.nlm.nih.gov/pubmed/11015440

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