Lack of Coreceptor Allows Survival of Chronically Stimulated Double-Negative α/β T Cells: Implications for Autoimmunity

Lymphoproliferative diseases are characterized by massive accumulation of CD4(−)CD8(−)B220(+) (double-negative [DN]) T cells in peripheral organs. Although evidence indicates these cells are derived from mature autoreactive α/β T cells, the significance of coreceptor downregulation is not known. In...

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Detalles Bibliográficos
Autores principales: Hamad, Abdel Rahim A., Srikrishnan, Ananth, Mirmonsef, Paria, Broeren, Chris P.M., June, Carl H., Pardoll, Drew, Schneck, Jonathan P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193322/
https://www.ncbi.nlm.nih.gov/pubmed/11369783

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