Bruton's Tyrosine Kinase Regulates the Activation of Gene Rearrangements at the λ Light Chain Locus in Precursor B Cells in the Mouse

Bruton's tyrosine kinase (Btk) is a nonreceptor tyrosine kinase involved in precursor B (pre-B) cell receptor signaling. Here we demonstrate that Btk-deficient mice have an ∼50% reduction in the frequency of immunoglobulin (Ig) λ light chain expression, already at the immature B cell stage in t...

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Detalles Bibliográficos
Autores principales: Dingjan, Gemma M., Middendorp, Sabine, Dahlenborg, Katarina, Maas, Alex, Grosveld, Frank, Hendriks, Rudolf W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193329/
https://www.ncbi.nlm.nih.gov/pubmed/11369788

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