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Antiviral Cd8(+) T Cell Responses in Neonatal Mice: Susceptibility to Polyoma Virus–Induced Tumors Is Associated with Lack of Cytotoxic Function by Viral Antigen–Specific T Cells
Polyoma virus is a potent oncogenic pathogen when inoculated into newborn mice of particular H-2(k) strains. Using D(k) tetramers containing the dominant antipolyoma CD8(+) T cell epitope, middle T protein (MT)389–397, and intracellular interferon γ staining, we enumerated MT389-specific CD8(+) T ce...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2001
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193393/ https://www.ncbi.nlm.nih.gov/pubmed/11238590 |