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Independence of Herpesvirus-Induced T Cell Lymphoma from Viral Cyclin D Homologue

Cyclin D family members are cellular protooncogenes, and their viral homologues in the Kaposi's sarcoma-associated herpesvirus (KSHV, human herpesvirus type 8 [HHV-8]) and the closely related Herpesvirus saimiri have been implicated as putative cofactors of viral transformation and pathogenesis...

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Autores principales: Ensser, Armin, Glykofrydes, Diana, Niphuis, Henk, Kuhn, Eva M., Rosenwirth, Brigitte, Heeney, Jonathan L., Niedobitek, Gerald, Müller-Fleckenstein, Ingrid, Fleckenstein, Bernhard
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193399/
https://www.ncbi.nlm.nih.gov/pubmed/11238594
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author Ensser, Armin
Glykofrydes, Diana
Niphuis, Henk
Kuhn, Eva M.
Rosenwirth, Brigitte
Heeney, Jonathan L.
Niedobitek, Gerald
Müller-Fleckenstein, Ingrid
Fleckenstein, Bernhard
author_facet Ensser, Armin
Glykofrydes, Diana
Niphuis, Henk
Kuhn, Eva M.
Rosenwirth, Brigitte
Heeney, Jonathan L.
Niedobitek, Gerald
Müller-Fleckenstein, Ingrid
Fleckenstein, Bernhard
author_sort Ensser, Armin
collection PubMed
description Cyclin D family members are cellular protooncogenes, and their viral homologues in the Kaposi's sarcoma-associated herpesvirus (KSHV, human herpesvirus type 8 [HHV-8]) and the closely related Herpesvirus saimiri have been implicated as putative cofactors of viral transformation and pathogenesis. KSHV is regularly found in Kaposi's sarcoma and in the primary effusion B cell lymphoma and Castleman's disease associated with immunosuppression and AIDS. H. saimiri strain C488 transforms human and marmoset T cells in vitro and causes polyclonal T cell lymphoma in New World monkeys. The viral cyclins stimulate cell cycle progression of quiescent fibroblasts, and they form active cyclin-dependent kinase (CDK)6 complexes of broad substrate specificity that can resist and downregulate cellular CDK inhibitors. This study shows that the viral cyclin of H. saimiri strain C488 is not required for viral replication, T cell transformation, and pathogenicity in New World primates.
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spelling pubmed-21933992008-04-14 Independence of Herpesvirus-Induced T Cell Lymphoma from Viral Cyclin D Homologue Ensser, Armin Glykofrydes, Diana Niphuis, Henk Kuhn, Eva M. Rosenwirth, Brigitte Heeney, Jonathan L. Niedobitek, Gerald Müller-Fleckenstein, Ingrid Fleckenstein, Bernhard J Exp Med Brief Definitive Report Cyclin D family members are cellular protooncogenes, and their viral homologues in the Kaposi's sarcoma-associated herpesvirus (KSHV, human herpesvirus type 8 [HHV-8]) and the closely related Herpesvirus saimiri have been implicated as putative cofactors of viral transformation and pathogenesis. KSHV is regularly found in Kaposi's sarcoma and in the primary effusion B cell lymphoma and Castleman's disease associated with immunosuppression and AIDS. H. saimiri strain C488 transforms human and marmoset T cells in vitro and causes polyclonal T cell lymphoma in New World monkeys. The viral cyclins stimulate cell cycle progression of quiescent fibroblasts, and they form active cyclin-dependent kinase (CDK)6 complexes of broad substrate specificity that can resist and downregulate cellular CDK inhibitors. This study shows that the viral cyclin of H. saimiri strain C488 is not required for viral replication, T cell transformation, and pathogenicity in New World primates. The Rockefeller University Press 2001-03-05 /pmc/articles/PMC2193399/ /pubmed/11238594 Text en © 2001 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Report
Ensser, Armin
Glykofrydes, Diana
Niphuis, Henk
Kuhn, Eva M.
Rosenwirth, Brigitte
Heeney, Jonathan L.
Niedobitek, Gerald
Müller-Fleckenstein, Ingrid
Fleckenstein, Bernhard
Independence of Herpesvirus-Induced T Cell Lymphoma from Viral Cyclin D Homologue
title Independence of Herpesvirus-Induced T Cell Lymphoma from Viral Cyclin D Homologue
title_full Independence of Herpesvirus-Induced T Cell Lymphoma from Viral Cyclin D Homologue
title_fullStr Independence of Herpesvirus-Induced T Cell Lymphoma from Viral Cyclin D Homologue
title_full_unstemmed Independence of Herpesvirus-Induced T Cell Lymphoma from Viral Cyclin D Homologue
title_short Independence of Herpesvirus-Induced T Cell Lymphoma from Viral Cyclin D Homologue
title_sort independence of herpesvirus-induced t cell lymphoma from viral cyclin d homologue
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193399/
https://www.ncbi.nlm.nih.gov/pubmed/11238594
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