Absence of Mitochondrial Superoxide Dismutase Results in a Murine Hemolytic Anemia Responsive to Therapy with a Catalytic Antioxidant

Manganese superoxide dismutase 2 (SOD2) is a critical component of the mitochondrial pathway for detoxification of O(2) (−), and targeted disruption of this locus leads to embryonic or neonatal lethality in mice. To follow the effects of SOD2 deficiency in cells over a longer time course, we created...

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Detalles Bibliográficos
Autores principales: Friedman, Jeff S., Rebel, Vivienne I., Derby, Ryan, Bell, Kirsten, Huang, Ting-Ting, Kuypers, Frans A., Epstein, Charles J., Burakoff, Steven J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193409/
https://www.ncbi.nlm.nih.gov/pubmed/11304553

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