An Endoplasmic Reticulum Retention Function for the Cytoplasmic Tail of the Human Pre–T Cell Receptor (Tcr) α Chain: Potential Role in the Regulation of Cell Surface Pre-Tcr Expression Levels

The pre-T cell receptor (TCR), which consists of a TCR-β chain paired with pre–TCR-α (pTα) and associated with CD3/ζ components, is a critical regulator of T cell development. For unknown reasons, extremely low pre-TCR levels reach the plasma membrane of pre-T cells. By transfecting chimeric TCR-α–p...

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Detalles Bibliográficos
Autores principales: Carrasco, Yolanda R., Ramiro, Almudena R., Trigueros, César, de Yébenes, Virginia G., García-Peydró, Marina, Toribio, María L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193431/
https://www.ncbi.nlm.nih.gov/pubmed/11342589

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