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Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail

To determine the function of immunoglobulin (Ig)α immunoreceptor tyrosine–based activation motif (ITAM) phosphorylation, we generated mice in which Igα ITAM tyrosines were replaced by phenylalanines (Igα(FF/FF)). Igα(FF/FF)mice had a specific reduction of B1 and marginal zone B cells, whereas B2 cel...

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Detalles Bibliográficos
Autores principales:	Kraus, Manfred, Pao, Lily I., Reichlin, Amy, Hu, Yun, Canono, Beth, Cambier, John C., Nussenzweig, Michel C., Rajewsky, Klaus
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2001
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193498/ https://www.ncbi.nlm.nih.gov/pubmed/11514602

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