Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo

Transcription factor GATA-1 reprograms immature myeloid cells to three different hematopoietic lineages-erythroid cells, megakaryocytes, and eosinophils. GATA-1 is essential for maturation of erythroid and megakaryocytic precursors, as revealed by gene targeting in mice. Here we demonstrate that del...

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Detalles Bibliográficos
Autores principales: Yu, Channing, Cantor, Alan B., Yang, Haidi, Browne, Carol, Wells, Richard A., Fujiwara, Yuko, Orkin, Stuart H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193547/
https://www.ncbi.nlm.nih.gov/pubmed/12045237
http://dx.doi.org/10.1084/jem.20020656

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