Intrinsic Defect in T Cell Production of Interleukin (IL)-13 in the Absence of Both IL-5 and Eotaxin Precludes the Development of Eosinophilia and Airways Hyperreactivity in Experimental Asthma

Interleukin (IL)-5 and IL-13 are thought to play key roles in the pathogenesis of asthma. Although both cytokines use eotaxin to regulate eosinophilia, IL-13 is thought to operate a separate pathway to IL-5 to induce airways hyperreactivity (AHR) in the allergic lung. However, identification of the...

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Detalles Bibliográficos
Autores principales: Mattes, Joerg, Yang, Ming, Mahalingam, Surendran, Kuehr, Joachim, Webb, Dianne C., Simson, Ljubov, Hogan, Simon P., Koskinen, Aulikki, McKenzie, Andrew N.J., Dent, Lindsay A., Rothenberg, Marc E., Matthaei, Klaus I., Young, Ian G., Foster, Paul S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193548/
https://www.ncbi.nlm.nih.gov/pubmed/12045241
http://dx.doi.org/10.1084/jem.20020009

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