Cargando…

Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation

Regulation by transforming growth factor (TGF)-β plays an important role in immune homeostasis. TGF-β inhibits T cell functions by blocking both proliferation and differentiation. Here we show that TGF-β blocks Th1 differentiation by inhibiting the expression of T-bet, the apparent masterregulator o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gorelik, Leonid, Constant, Stephanie, Flavell, Richard A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193549/ https://www.ncbi.nlm.nih.gov/pubmed/12045248 http://dx.doi.org/10.1084/jem.20012076

Ejemplares similares

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis
por: Akiba, Hisaya, et al.
Publicado: (2000)

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer
por: Naoe, Yoshinori, et al.
Publicado: (2007)

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s
por: Bonecchi, Raffaella, et al.
Publicado: (1998)

GATA-3 in Human T Cell Helper Type 2 Development
por: Skapenko, Alla, et al.
Publicado: (2004)

A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells
por: Borkowski, Teresa A., et al.
Publicado: (1996)

T follicular helper cells differentiate from Th2 cells in response to helminth antigens
por: Zaretsky, Arielle Glatman, et al.
Publicado: (2009)

Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen
por: Eisenbarth, Stephanie C., et al.
Publicado: (2002)

Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function
por: Lehnertz, Bernhard, et al.
Publicado: (2010)

An Instructive Component in T Helper Cell Type 2 (Th2) Development Mediated by Gata-3
por: Farrar, J. David, et al.
Publicado: (2001)

Transforming Growth Factor β1, in the Presence of Granulocyte/Macrophage Colony-stimulating Factor and Interleukin 4, Induces Differentiation of Human Peripheral Blood Monocytes into Dendritic Langerhans Cells
por: Geissmann, Frederic, et al.
Publicado: (1998)

NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor β1 production
por: Kim, Hye Young, et al.
Publicado: (2005)

Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4(+) T cells
por: Ciucci, Thomas, et al.
Publicado: (2021)

Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy
por: Morita, Akimichi, et al.
Publicado: (1997)

Human Nerve Growth Factor Protects Common Marmosets against Autoimmune Encephalomyelitis by Switching the Balance of T Helper Cell Type 1 and 2 Cytokines within the Central Nervous System
por: Villoslada, Pablo, et al.
Publicado: (2000)

Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors
por: Löhning, Max, et al.
Publicado: (2008)

A Signal Transducer and Activator of Transcription (Stat)4-independent Pathway for the Development of T Helper Type 1 Cells
por: Kaplan, Mark H., et al.
Publicado: (1998)

Autocrine/paracrine TGFβ1 is required for the development of epidermal Langerhans cells
por: Kaplan, Daniel H., et al.
Publicado: (2007)

P-Selectin Glycoprotein Ligand-1 (PSGL-1) on T Helper 1 but Not on T Helper 2 Cells Binds to P-Selectin and Supports Migration into Inflamed Skin
por: Borges, Eric, et al.
Publicado: (1997)

Primary Role for GI Protein Signaling in the Regulation of Interleukin 12 Production and the Induction of T Helper Cell Type 1 Responses
por: He, Jianping, et al.
Publicado: (2000)

Anti–Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in the Presence of Lipopolysaccharide
por: Castro, Antonio G., et al.
Publicado: (2000)

T1/St2-Deficient Mice Demonstrate the Importance of T1/St2 in Developing Primary T Helper Cell Type 2 Responses
por: Townsend, Michael J., et al.
Publicado: (2000)

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2
por: Hirai, Hiroyuki, et al.
Publicado: (2001)

The Absence of Interleukin 1 Receptor–Related T1/St2 Does Not Affect T Helper Cell Type 2 Development and Its Effector Function
por: Hoshino, Katsuaki, et al.
Publicado: (1999)

Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens
por: Tian, Jide, et al.
Publicado: (1997)

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
por: Villarino, Alejandro V., et al.
Publicado: (2007)

LACK OF A CORRELATION BETWEEN CELL-MEDIATED IMMUNITY TO THE CARRIER AND THE CARRIER-HAPTEN HELPER EFFECT
por: Liew, F. Y., et al.
Publicado: (1974)

A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations
por: Baekkevold, Espen S., et al.
Publicado: (2005)

Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers
por: Moriyama, Saya, et al.
Publicado: (2014)

Immunotherapy of Cytotoxic T Cell–resistant Tumors by T Helper 2 Cells: An Eotaxin and STAT6-dependent Process
por: Mattes, Joerg, et al.
Publicado: (2003)

CD28-independent Induction of T Helper Cells and Immunoglobulin Class Switches Requires Costimulation by the Heat-stable Antigen
por: Wu, Yan, et al.
Publicado: (1998)

Inflammasome recognition of influenza virus is essential for adaptive immune responses
por: Ichinohe, Takeshi, et al.
Publicado: (2009)

Infectious Tolerance: Human CD25(+) Regulatory T Cells Convey Suppressor Activity to Conventional CD4(+) T Helper Cells
por: Jonuleit, Helmut, et al.
Publicado: (2002)

Two Subsets of Naive T Helper Cells with Distinct T Cell Receptor Excision Circle Content in Human Adult Peripheral Blood
por: Kimmig, Sonja, et al.
Publicado: (2002)

IL-4–producing CD4(+) T cells in reactive lymph nodes during helminth infection are T follicular helper cells
por: King, Irah L., et al.
Publicado: (2009)

Invariant Chain Controls H2-M Proteolysis in Mouse Splenocytes and Dendritic Cells
por: Pierre, Philippe, et al.
Publicado: (2000)

Immature Dendritic Cells Acquire Cd8(+)Cytotoxic T Lymphocyte Priming Capacity upon Activation by T Helper Cell–Independent or–Dependent Stimuli
por: Schuurhuis, Danita H., et al.
Publicado: (2000)

P-Selectin Glycoprotein Ligand 1 (Psgl-1) Is a Physiological Ligand for E-Selectin in Mediating T Helper 1 Lymphocyte Migration
por: Hirata, Takako, et al.
Publicado: (2000)

An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation
por: Fong, Carol Ho Yan, et al.
Publicado: (2008)

Anti–4-1bb Monoclonal Antibodies Abrogate T Cell–Dependent Humoral Immune Responses in Vivo through the Induction of Helper T Cell Anergy
por: Mittler, Robert S., et al.
Publicado: (1999)

Arkadia-SKI/SnoN signaling differentially regulates TGF-β–induced iTreg and Th17 cell differentiation
por: Xu, Hao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3fkg8t5geor2h6pscf6bcufh4q