Vaccination with Heat-killed Leishmania Antigen or Recombinant Leishmanial Protein and CpG Oligodeoxynucleotides Induces Long-Term Memory CD4(+)and CD8(+)T Cell Responses and Protection Against Leishmania major Infection

CpG oligodeoxynucleotides (ODN) have potent effects on innate and adaptive cellular immune responses. In this report, the ability of CpG ODN to confer long-term immunity and protection when used as a vaccine adjuvant with a clinical grade of leishmanial antigen, autoclaved Leishmania major (ALM), or...

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Detalles Bibliográficos
Autores principales: Rhee, Elizabeth G., Mendez, Susana, Shah, Javeed A., Wu, Chang-you, Kirman, Joanna R., Turon, Tara N., Davey, Dylan F., Davis, Heather, Klinman, Dennis M., Coler, Rhea N., Sacks, David L., Seder, Robert A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193566/
https://www.ncbi.nlm.nih.gov/pubmed/12070284
http://dx.doi.org/10.1084/jem.20020147

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