Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

Natural killer (NK) cells and interferon (IFN)-γ have been implicated in immune surveillance against tumor development. Here we show that tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) plays a critical role in the NK cell–mediated and IFN-γ–dependent tumor surveillance. Administrati...

Descripción completa

Detalles Bibliográficos
Autores principales: Takeda, Kazuyoshi, Smyth, Mark J., Cretney, Erika, Hayakawa, Yoshihiro, Kayagaki, Nobuhiko, Yagita, Hideo, Okumura, Ko
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193611/
https://www.ncbi.nlm.nih.gov/pubmed/11805143
http://dx.doi.org/10.1084/jem.20011171
_version_ 1782147511740268544
author Takeda, Kazuyoshi
Smyth, Mark J.
Cretney, Erika
Hayakawa, Yoshihiro
Kayagaki, Nobuhiko
Yagita, Hideo
Okumura, Ko
author_facet Takeda, Kazuyoshi
Smyth, Mark J.
Cretney, Erika
Hayakawa, Yoshihiro
Kayagaki, Nobuhiko
Yagita, Hideo
Okumura, Ko
author_sort Takeda, Kazuyoshi
collection PubMed
description Natural killer (NK) cells and interferon (IFN)-γ have been implicated in immune surveillance against tumor development. Here we show that tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) plays a critical role in the NK cell–mediated and IFN-γ–dependent tumor surveillance. Administration of neutralizing monoclonal antibody against TRAIL promoted tumor development in mice subcutaneously inoculated with a chemical carcinogen methylcholanthrene (MCA). This protective effect of TRAIL was at least partly mediated by NK cells and totally dependent on IFN-γ. In the absence of TRAIL, NK cells, or IFN-γ, TRAIL-sensitive sarcomas preferentially emerged in MCA-inoculated mice. Moreover, development of spontaneous tumors in p53(+/−) mice was also promoted by neutralization of TRAIL. These results indicated a substantial role of TRAIL as an effector molecule that eliminates developing tumors.
format Text
id pubmed-2193611
institution National Center for Biotechnology Information
language English
publishDate 2002
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21936112008-04-14 Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development Takeda, Kazuyoshi Smyth, Mark J. Cretney, Erika Hayakawa, Yoshihiro Kayagaki, Nobuhiko Yagita, Hideo Okumura, Ko J Exp Med Original Article Natural killer (NK) cells and interferon (IFN)-γ have been implicated in immune surveillance against tumor development. Here we show that tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) plays a critical role in the NK cell–mediated and IFN-γ–dependent tumor surveillance. Administration of neutralizing monoclonal antibody against TRAIL promoted tumor development in mice subcutaneously inoculated with a chemical carcinogen methylcholanthrene (MCA). This protective effect of TRAIL was at least partly mediated by NK cells and totally dependent on IFN-γ. In the absence of TRAIL, NK cells, or IFN-γ, TRAIL-sensitive sarcomas preferentially emerged in MCA-inoculated mice. Moreover, development of spontaneous tumors in p53(+/−) mice was also promoted by neutralization of TRAIL. These results indicated a substantial role of TRAIL as an effector molecule that eliminates developing tumors. The Rockefeller University Press 2002-01-21 /pmc/articles/PMC2193611/ /pubmed/11805143 http://dx.doi.org/10.1084/jem.20011171 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Original Article
Takeda, Kazuyoshi
Smyth, Mark J.
Cretney, Erika
Hayakawa, Yoshihiro
Kayagaki, Nobuhiko
Yagita, Hideo
Okumura, Ko
Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development
title Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development
title_full Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development
title_fullStr Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development
title_full_unstemmed Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development
title_short Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development
title_sort critical role for tumor necrosis factor–related apoptosis-inducing ligand in immune surveillance against tumor development
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193611/
https://www.ncbi.nlm.nih.gov/pubmed/11805143
http://dx.doi.org/10.1084/jem.20011171
work_keys_str_mv AT takedakazuyoshi criticalrolefortumornecrosisfactorrelatedapoptosisinducingligandinimmunesurveillanceagainsttumordevelopment
AT smythmarkj criticalrolefortumornecrosisfactorrelatedapoptosisinducingligandinimmunesurveillanceagainsttumordevelopment
AT cretneyerika criticalrolefortumornecrosisfactorrelatedapoptosisinducingligandinimmunesurveillanceagainsttumordevelopment
AT hayakawayoshihiro criticalrolefortumornecrosisfactorrelatedapoptosisinducingligandinimmunesurveillanceagainsttumordevelopment
AT kayagakinobuhiko criticalrolefortumornecrosisfactorrelatedapoptosisinducingligandinimmunesurveillanceagainsttumordevelopment
AT yagitahideo criticalrolefortumornecrosisfactorrelatedapoptosisinducingligandinimmunesurveillanceagainsttumordevelopment
AT okumurako criticalrolefortumornecrosisfactorrelatedapoptosisinducingligandinimmunesurveillanceagainsttumordevelopment

Ejemplares similares