Cargando…

Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance

Using a tumor model of spontaneously arising insulinomas expressing a defined tumor-associated antigen, we investigated whether tumor growth promotes cross-presentation and tolerance of tumor-specific T cells. We found that an advanced tumor burden enhanced cross-presentation of tumor-associated ant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Linh T., Elford, Alisha R., Murakami, Kiichi, Garza, Kristine M., Schoenberger, Stephen P., Odermatt, Bernhard, Speiser, Daniel E., Ohashi, Pamela S.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193619/ https://www.ncbi.nlm.nih.gov/pubmed/11854356 http://dx.doi.org/10.1084/jem.20010032

Ejemplares similares

Role of Antigen-Presenting Cells in Mediating Tolerance and Autoimmunity
por: Garza, Kristine M., et al.
Publicado: (2000)

PKCθ Signals Activation versus Tolerance In Vivo
por: Berg-Brown, Nancy N., et al.
Publicado: (2004)

Peptide-Pulsed Dendritic Cells Have Superior Ability to Induce Immune-Mediated Tissue Destruction Compared to Peptide with Adjuvant
por: Dissanayake, Dilan, et al.
Publicado: (2014)

Different Toll-Like Receptor Stimuli Have a Profound Impact on Cytokines Required to Break Tolerance and Induce Autoimmunity
por: Lin, Albert C. C., et al.
Publicado: (2011)

Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes
por: Ono, Nobuyuki, et al.
Publicado: (2017)

Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity
por: Tran, Charles W., et al.
Publicado: (2020)

Shp1 regulates T cell homeostasis by limiting IL-4 signals
por: Johnson, Dylan J., et al.
Publicado: (2013)

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy
por: Speiser, Daniel E., et al.
Publicado: (1997)

Overproduction of IL-2 by Cbl-b deficient CD4(+) T cells provides resistance against regulatory T cells
por: Han, SeongJun, et al.
Publicado: (2020)

CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly
por: Jones, Russell G., et al.
Publicado: (2002)

Development of an adoptive cell therapy protocol with tumor-infiltrating lymphocytes and intermediate-dose interleukin-2 therapy
por: Nguyen, Linh T, et al.
Publicado: (2013)

Overproduction of IFNγ by Cbl-b–Deficient CD8(+) T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity
por: Han, SeongJun, et al.
Publicado: (2022)

Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test
por: Babbar, Rohit, et al.
Publicado: (2018)

Limited Granulomatosis With Polyangiitis Presenting as Recurrent Lung Abscess Without Pneumonia
por: Chippa, Venu, et al.
Publicado: (2022)

Valeurs limites tolérables
por: Commissariat General à la Promotion du Travail. Brussels
Publicado: (1979)

Thermal Tolerance Limits of Diamondback Moth in Ramping and Plunging Assays
por: Nguyen, Chi, et al.
Publicado: (2014)

Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8(+) T Cells to Cause Immunopathology
por: Ehl, Stephan, et al.
Publicado: (1998)

Knockout of the entire family of AITR genes in Arabidopsis leads to enhanced drought and salinity tolerance without fitness costs
por: Chen, Siyu, et al.
Publicado: (2021)

High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation
por: MacGregor, Heather L., et al.
Publicado: (2019)

Limitations of present searches
por: Polesello, Giacomo
Publicado: (2011)

Negative Regulation of T Cell Proliferation and Interleukin 2 Production by the Serine Threonine Kinase Gsk-3
por: Ohteki, Toshiaki, et al.
Publicado: (2000)

ICD lead abandonment is without risk? A case of “lead on lead crime”
por: Rizkallah, Jacques, et al.
Publicado: (2015)

Use of clinical tolerance limits for assessing agreement
por: Taffé, Patrick
Publicado: (2022)

Nutrient Limitation Mimics Artemisinin Tolerance in Malaria
por: Brown, Audrey C., et al.
Publicado: (2023)

Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells
por: Amin, Mohammed Abdullahel, et al.
Publicado: (2008)

Leading trait dimensions in flood-tolerant plants
por: Pan, Yingji, et al.
Publicado: (2022)

A night without limits for science
por: CERN Bulletin
Publicado: (2010)

Wealth Without Limits: in Defense of Billionaires
por: Flanigan, Jessica, et al.
Publicado: (2022)

β-Lactamase Genes without Limits
por: Naas, Thierry, et al.
Publicado: (2023)

Pulmonary and Physical Function Limitations in Aging Men with and without HIV from the Multicenter AIDS Cohort Study
por: Abdo, Mona, et al.
Publicado: (2021)

The Limitations of Surgery, Past and Present
por: Young, Archibald
Publicado: (1924)

Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs
por: Bruun, Donald A., et al.
Publicado: (2023)

Machine learning approaches for predicting Cracking Tolerance Index (CTIndex) of asphalt concrete containing reclaimed asphalt pavement
por: Nguyen, Lan Ngoc, et al.
Publicado: (2023)

Protein Changes in Response to Lead Stress of Lead-Tolerant and Lead-Sensitive Industrial Hemp Using SWATH Technology
por: Xia, Cheng, et al.
Publicado: (2019)

Tolerances to limit the vertical emittance in future storage rings
por: Raubenheimer, T O
Publicado: (1991)

Resource limitation, tolerance, and the future of ecological plant classification
por: Craine, Joseph M., et al.
Publicado: (2012)

Limited immune tolerance induced by transient mixed chimerism
por: Yu, Ji Hyun, et al.
Publicado: (2015)

Development of Drought-Tolerant Transgenic Wheat: Achievements and Limitations
por: Khan, Shahbaz, et al.
Publicado: (2019)

Improving the tolerability of osimertinib by identifying its toxic limit
por: Agema, Bram C., et al.
Publicado: (2022)

Limited Internal Comparability of General Intelligence Composites: Impact on External Validity, Possible Predictors, and Practical Remedies
por: Grieder, Silvia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5mdl4jt96jl4ud42khqpogajm0