Thymic Selection Generates a Large T Cell Pool Recognizing a Self-Peptide in Humans

The low frequency of self-peptide–specific T cells in the human preimmune repertoire has so far precluded their direct evaluation. Here, we report an unexpected high frequency of T cells specific for the self-antigen Melan-A/MART-1 in CD8 single–positive thymocytes from human histocompatibility leuk...

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Detalles Bibliográficos
Autores principales: Zippelius, Alfred, Pittet, Mikaël J., Batard, Pascal, Rufer, Nathalie, de Smedt, Magda, Guillaume, Philippe, Ellefsen, Kim, Valmori, Danila, Liénard, Danielle, Plum, Jean, MacDonald, H. Robson, Speiser, Daniel E., Cerottini, Jean-Charles, Romero, Pedro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193620/
https://www.ncbi.nlm.nih.gov/pubmed/11854361
http://dx.doi.org/10.1084/jem.20011658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193620/
https://www.ncbi.nlm.nih.gov/pubmed/11854361
http://dx.doi.org/10.1084/jem.20011658

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