Cargando…

Thymic Selection Generates a Large T Cell Pool Recognizing a Self-Peptide in Humans

The low frequency of self-peptide–specific T cells in the human preimmune repertoire has so far precluded their direct evaluation. Here, we report an unexpected high frequency of T cells specific for the self-antigen Melan-A/MART-1 in CD8 single–positive thymocytes from human histocompatibility leuk...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zippelius, Alfred, Pittet, Mikaël J., Batard, Pascal, Rufer, Nathalie, de Smedt, Magda, Guillaume, Philippe, Ellefsen, Kim, Valmori, Danila, Liénard, Danielle, Plum, Jean, MacDonald, H. Robson, Speiser, Daniel E., Cerottini, Jean-Charles, Romero, Pedro
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193620/ https://www.ncbi.nlm.nih.gov/pubmed/11854361 http://dx.doi.org/10.1084/jem.20011658

Ejemplares similares

In Vivo Expression of Natural Killer Cell Inhibitory Receptors by Human Melanoma–Specific Cytolytic T Lymphocytes
por: Speiser, Daniel E., et al.
Publicado: (1999)

High Frequencies of Naive Melan-a/Mart-1–Specific Cd8(+) T Cells in a Large Proportion of Human Histocompatibility Leukocyte Antigen (Hla)-A2 Individuals
por: Pittet, Mikaël J., et al.
Publicado: (1999)

Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes
por: Romero, Pedro, et al.
Publicado: (1998)

Degeneracy of Antigen Recognition as the Molecular Basis for the High Frequency of Naive A2/Melan-A Peptide Multimer(+) CD8(+) T Cells in Humans
por: Dutoit, Valérie, et al.
Publicado: (2002)

Modulation of Proteasomal Activity Required for the Generation of a Cytotoxic T Lymphocyte–defined Peptide Derived from the Tumor Antigen MAGE-3
por: Valmori, Danila, et al.
Publicado: (1999)

Tumor Cell Recognition Efficiency by T Cells
por: Speiser, Daniel E, et al.
Publicado: (2005)

GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO : III. Velocity Sedimentation Studies of the Differentiation and Fate of Effector Cells in Long-Term Mixed Leukocyte Cultures
por: MacDonald, H. Robson, et al.
Publicado: (1974)

GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO : I. RESPONSE OF NORMAL AND IMMUNE MOUSE SPLEEN CELLS IN MIXED LEUKOCYTE CULTURES
por: Cerottini, Jean-Charles, et al.
Publicado: (1974)

GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO : II. EFFECT OF REPEATED EXPOSURE TO ALLOANTIGENS ON THE CYTOTOXIC ACTIVITY OF LONG-TERM MIXED LEUKOCYTE CULTURES
por: MacDonald, H. Robson, et al.
Publicado: (1974)

FRI564 Thymic Hyperplasia In Graves' Disease: An Under-recognized Association
por: Nachum, Sapir, et al.
Publicado: (2023)

Using Modified Antigenic Sequences to Develop Cancer Vaccines: Are We Losing the Focus?
por: Valmori, Danila, et al.
Publicado: (2004)

Immune Responses to the Cancer Testis Antigen XAGE-1b in Non Small Cell Lung Cancer Caucasian Patients
por: Saito, Kanako, et al.
Publicado: (2016)

An Adult Thymic Stromal-Cell Suspension Model for in Vitro Positive Selection
por: Chidgey, Ann P., et al.
Publicado: (1998)

The Role of the Thymus and Recent Thymic Migrants in the Maintenance of the Adult Peripheral Lymphocyte Pool
por: Berzins, S.P., et al.
Publicado: (1998)

Constant regulation for stable CD8 T‐cell functional avidity and its possible implications for cancer immunotherapy
por: Gilfillan, Connie B., et al.
Publicado: (2021)

Modulation of Cytokine Secretion Allows CD4 T Cells Secreting IL-10 and IL-17 to Simultaneously Participate in Maintaining Tolerance and Immunity
por: Saito, Kanako, et al.
Publicado: (2015)

Correction: Immune Responses to the Cancer Testis Antigen XAGE-1b in Non Small Cell Lung Cancer Caucasian Patients
por: Sardaro, Alessandro, et al.
Publicado: (2016)

Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire
por: van Meerwijk, Joost P.M., et al.
Publicado: (1997)

Analysis of Immature (CD4(–)CD8(–)) Thymic Subsets in T-Cell Receptor αß Transgenic Mice
por: Wilson, Anne, et al.
Publicado: (1992)

Profile of a Serial Killer: Cellular and Molecular Approaches to Study Individual Cytotoxic T-Cells following Therapeutic Vaccination
por: Iancu, Emanuela M., et al.
Publicado: (2011)

A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β
por: Ucar, Olga, et al.
Publicado: (2016)

Premature thymic involution is independent of structural plasticity of the thymic stroma
por: Franckaert, Dean, et al.
Publicado: (2015)

THE IMMUNOGENICITY OF ANTIGEN BOUND TO THE PLASMA MEMBRANE OF MACROPHAGES
por: Unanue, Emil R., et al.
Publicado: (1970)

Antibody directed to determinants of a Moloney virus derived MCF GP70 recognizes a thymic differentiation antigen
Publicado: (1983)

Thymic Lymphoma with Thymic Cyst
por: Haque, Anwar Ul, et al.
Publicado: (1994)

Heterogeneity assessment of functional T cell avidity
por: Ioannidou, Kalliopi, et al.
Publicado: (2017)

Molecular Insights for Optimizing T Cell Receptor Specificity Against Cancer
por: Hebeisen, Michael, et al.
Publicado: (2013)

Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens
por: Hebeisen, Michael, et al.
Publicado: (2015)

Recognizing Sequences of Sequences
por: Kiebel, Stefan J., et al.
Publicado: (2009)

Characterization of Human Thymic Exosomes
por: Skogberg, Gabriel, et al.
Publicado: (2013)

Reliability Models Applied to a System of Power Converters in Particle Accelerators
por: Siemaszko, D, et al.
Publicado: (2012)

THYMUS-DERIVED (T) CELL IMMUNOGLOBULINS : PRESENCE OF A RECEPTOR SITE FOR IGG AND ABSENCE OF LARGE AMOUNTS OF "BURIED" IG DETERMINANTS ON T CELLS
por: Grey, Howard M., et al.
Publicado: (1972)

Tertiary Lymphoid Structures as a Predictive Biomarker of Response to Cancer Immunotherapies
por: Trüb, Marta, et al.
Publicado: (2021)

Human melanoma-specific CD8(+) T-cells from metastases are capable of antigen-specific degranulation and cytolysis directly ex vivo
por: Mahnke, Yolanda D., et al.
Publicado: (2012)

Key components of chemotherapy for thymic malignancies: a systematic review and pooled analysis for anthracycline-, carboplatin- or cisplatin-based chemotherapy
por: Okuma, Yusuke, et al.
Publicado: (2014)

Energy storage: systems and components
por: Rufer, Alfred
Publicado: (2017)

Optimal management of thymic malignancies: current perspectives
por: Drevet, Gabrielle, et al.
Publicado: (2019)

COMPARISON OF THE IMMUNE RESPONSIVENESS OF NZB AND NZB x NZW F(1) HYBRID MICE WITH THAT OF OTHER STRAINS OF MICE
por: Cerottini, Jean-Charles, et al.
Publicado: (1969)

Expression of RAGE and HMGB1 in Thymic Epithelial Tumors, Thymic Hyperplasia and Regular Thymic Morphology
por: Moser, Bernhard, et al.
Publicado: (2014)

Thymic Neuroblastoma within a Thymic Cyst in an Adult
por: Ueda, Yuichiro, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_mu16brr4185gejj5dpbkdhtqjc