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Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG

It is widely accepted that immunoglobulin (Ig)E triggers immediate hypersensitivity responses by activating a cognate high-affinity receptor, FcεRI, leading to mast cell degranulation with release of vasoactive and proinflammatory mediators. This apparent specificity, however, is complicated by the...

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Autores principales: Ujike, Azusa, Ishikawa, Yoko, Ono, Masao, Yuasa, Takae, Yoshino, Tadashi, Fukumoto, Manabu, Ravetch, Jeffrey V., Takai, Toshiyuki
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193631/
https://www.ncbi.nlm.nih.gov/pubmed/10330436
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author Ujike, Azusa
Ishikawa, Yoko
Ono, Masao
Yuasa, Takae
Yoshino, Tadashi
Fukumoto, Manabu
Ravetch, Jeffrey V.
Takai, Toshiyuki
author_facet Ujike, Azusa
Ishikawa, Yoko
Ono, Masao
Yuasa, Takae
Yoshino, Tadashi
Fukumoto, Manabu
Ravetch, Jeffrey V.
Takai, Toshiyuki
author_sort Ujike, Azusa
collection PubMed
description It is widely accepted that immunoglobulin (Ig)E triggers immediate hypersensitivity responses by activating a cognate high-affinity receptor, FcεRI, leading to mast cell degranulation with release of vasoactive and proinflammatory mediators. This apparent specificity, however, is complicated by the ability of IgE to bind with low affinity to Fc receptors for IgG, FcγRII and III. We have addressed the in vivo significance of this interaction by studying IgE-mediated passive systemic anaphylaxis in FcγR-deficient mice. Mice deficient in the inhibitory receptor for IgG, FcγRIIB, display enhanced IgE-mediated anaphylactic responses, whereas mice deficient in an IgG activation receptor, FcγRIII, display a corresponding attenuation of IgE-mediated responses. Thus, in addition to modulating IgG-triggered hypersensitivity responses, FcγRII and III on mast cells are potent regulators of IgE-mediated responses and reveal the existence of a regulatory pathway for IgE triggering of effector cells through IgG Fc receptors that could contribute to the etiology of the atopic response.
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spelling pubmed-21936312008-04-16 Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG Ujike, Azusa Ishikawa, Yoko Ono, Masao Yuasa, Takae Yoshino, Tadashi Fukumoto, Manabu Ravetch, Jeffrey V. Takai, Toshiyuki J Exp Med Articles It is widely accepted that immunoglobulin (Ig)E triggers immediate hypersensitivity responses by activating a cognate high-affinity receptor, FcεRI, leading to mast cell degranulation with release of vasoactive and proinflammatory mediators. This apparent specificity, however, is complicated by the ability of IgE to bind with low affinity to Fc receptors for IgG, FcγRII and III. We have addressed the in vivo significance of this interaction by studying IgE-mediated passive systemic anaphylaxis in FcγR-deficient mice. Mice deficient in the inhibitory receptor for IgG, FcγRIIB, display enhanced IgE-mediated anaphylactic responses, whereas mice deficient in an IgG activation receptor, FcγRIII, display a corresponding attenuation of IgE-mediated responses. Thus, in addition to modulating IgG-triggered hypersensitivity responses, FcγRII and III on mast cells are potent regulators of IgE-mediated responses and reveal the existence of a regulatory pathway for IgE triggering of effector cells through IgG Fc receptors that could contribute to the etiology of the atopic response. The Rockefeller University Press 1999-05-17 /pmc/articles/PMC2193631/ /pubmed/10330436 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Ujike, Azusa
Ishikawa, Yoko
Ono, Masao
Yuasa, Takae
Yoshino, Tadashi
Fukumoto, Manabu
Ravetch, Jeffrey V.
Takai, Toshiyuki
Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG
title Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG
title_full Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG
title_fullStr Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG
title_full_unstemmed Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG
title_short Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG
title_sort modulation of immunoglobulin (ig)e-mediated systemic anaphylaxis by low-affinity fc receptors for igg
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193631/
https://www.ncbi.nlm.nih.gov/pubmed/10330436
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