Targeting Pyk2 to β1-Integrin–Containing Focal Contacts Rescues Fibronectin-Stimulated Signaling and Haptotactic Motility Defects of Focal Adhesion Kinase–Null Cells

Focal adhesion kinase–null (FAK(−/)−) fibroblasts exhibit morphological and motility defects that are reversed by focal adhesion kinase (FAK) reexpression. The FAK-related kinase, proline-rich tyrosine kinase 2 (Pyk2), is expressed in FAK(−/)− cells, yet it exhibits a perinuclear distribution and do...

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Detalles Bibliográficos
Autores principales: Klingbeil, Candice K., Hauck, Christof R., Hsia, Datsun A., Jones, K.C., Reider, Shannon R., Schlaepfer, David D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193658/
https://www.ncbi.nlm.nih.gov/pubmed/11149924

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