Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes: A Buried Alloreactive Mutation Subtly Alters Peptide Presentation Substantially Increasing V(β) Interactions

The crystal structures of the 2C/H-2K(bm3)–dEV8 allogeneic complex at 2.4 Å and H-2K(bm3)–dEV8 at 2.15 Å, when compared with their syngeneic counterparts, elucidate structural changes that induce an alloresponse. The Asp77Ser mutation that imbues H-2K(bm3)–dEV8 with its alloreactive properties is lo...

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Autores principales:	Luz, John G., Huang, Mingdong, Garcia, K. Christopher, Rudolph, Markus G., Apostolopoulos, Vasso, Teyton, Luc, Wilson, Ian A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193710/ https://www.ncbi.nlm.nih.gov/pubmed/11994422 http://dx.doi.org/10.1084/jem.20011644