Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes: A Buried Alloreactive Mutation Subtly Alters Peptide Presentation Substantially Increasing V(β) Interactions

The crystal structures of the 2C/H-2K(bm3)–dEV8 allogeneic complex at 2.4 Å and H-2K(bm3)–dEV8 at 2.15 Å, when compared with their syngeneic counterparts, elucidate structural changes that induce an alloresponse. The Asp77Ser mutation that imbues H-2K(bm3)–dEV8 with its alloreactive properties is lo...

Descripción completa