Cargando…

DNA Double-Strand Breaks: Prior to but not Sufficient in Targeting Hypermutation

The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination (CSR) of immunoglobulin (Ig) genes, both of which are associated with DNA double-strand breaks (DSBs). As AID is capable of deaminating deoxy-cytidine (dC) to deoxy-uracil (dU),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bross, Linda, Muramatsu, Masamichi, Kinoshita, Kazuo, Honjo, Tasuku, Jacobs, Heinz
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193713/ https://www.ncbi.nlm.nih.gov/pubmed/11994423 http://dx.doi.org/10.1084/jem.20011749

Ejemplares similares

Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region: Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation
por: Nagaoka, Hitoshi, et al.
Publicado: (2002)

DNA Double Strand Breaks Occur Independent of AID in Hypermutating Ig Genes
por: Bross, Linda, et al.
Publicado: (2003)

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice
por: Jansen, Jacob G., et al.
Publicado: (2006)

Unmutated Immunoglobulin M Can Protect Mice from Death by Influenza Virus Infection
por: Harada, Yuichi, et al.
Publicado: (2003)

ATM regulates ATR chromatin loading in response to DNA double-strand breaks
por: Cuadrado, Myriam, et al.
Publicado: (2006)

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation
por: Krijger, Peter H.L., et al.
Publicado: (2009)

The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination
por: Chahwan, Richard, et al.
Publicado: (2012)

Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks
por: Bhandoola, Avinash, et al.
Publicado: (2000)

RAG-induced DNA double-strand breaks signal through Pim2 to promote pre–B cell survival and limit proliferation
por: Bednarski, Jeffrey J., et al.
Publicado: (2012)

Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse
por: Delbos, Frédéric, et al.
Publicado: (2005)

Effects of Breeding Environments on Generation and Activation of Autoreactive B-1 Cells in Anti-red Blood Cell Autoantibody Transgenic Mice
por: Murakami, Masao, et al.
Publicado: (1997)

Somatic Hypermutation Shapes the Antibody Repertoire of Memory B Cells in Humans
por: Meffre, Eric, et al.
Publicado: (2001)

The Activation-induced Deaminase Functions in a Postcleavage Step of the Somatic Hypermutation Process
por: Papavasiliou, F. Nina, et al.
Publicado: (2002)

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice
por: Nishimura, Hiroyuki, et al.
Publicado: (2000)

DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
por: Delbos, Frédéric, et al.
Publicado: (2007)

XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes
por: Saribasak, Huseyin, et al.
Publicado: (2011)

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells
por: Rouaud, Pauline, et al.
Publicado: (2013)

Hypermutability of Damaged Single-Strand DNA Formed at Double-Strand Breaks and Uncapped Telomeres in Yeast Saccharomyces cerevisiae
por: Yang, Yong, et al.
Publicado: (2008)

Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation
por: Rajagopal, Deepa, et al.
Publicado: (2009)

Activation and Differentiation of Autoreactive B-1 Cells by Interleukin 10 Induce Autoimmune Hemolytic Anemia in Fas-deficient Antierythrocyte Immunoglobulin Transgenic Mice
por: Watanabe, Norihiko, et al.
Publicado: (2002)

Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation
por: Sakofsky, Cynthia J., et al.
Publicado: (2019)

Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells
por: Nguyen, Thuy Vy, et al.
Publicado: (2014)

Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers
por: Toellner, Kai-Michael, et al.
Publicado: (2002)

AID to overcome the limitations of genomic information by introducing somatic DNA alterations
por: Honjo, Tasuku, et al.
Publicado: (2006)

Correction: Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation
por: Sakofsky, Cynthia J., et al.
Publicado: (2020)

Somatic Hypermutation in the Absence of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-Pk(cs)) or Recombination-Activating Gene (Rag)1 Activity
por: Bemark, Mats, et al.
Publicado: (2000)

FACT and H3.3: New markers for the somatic hypermutation
por: Aida, Masatoshi, et al.
Publicado: (2013)

Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b (−/−) Pdcd1 (−/−) mice
por: Okazaki, Taku, et al.
Publicado: (2005)

Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40
por: Garceau, Norman, et al.
Publicado: (2000)

Cd8 Expression up to the Double-Positive CD3(Low/Intermediate) Stage of Thymic Differentiation Is Sufficient for Development of Peripheral Functional Cytotoxic T Lymphocytes
por: Zhang, X.-L., et al.
Publicado: (2001)

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
por: Caskey, Marina, et al.
Publicado: (2011)

Histone Acetylation Determines the Developmentally Regulated Accessibility for T Cell Receptor γ Gene Recombination
por: Agata, Yasutoshi, et al.
Publicado: (2001)

TRANCE Is Necessary and Sufficient for Osteoblast-mediated Activation of Bone Resorption in Osteoclasts
por: Fuller, Karen, et al.
Publicado: (1998)

Hypermutation in single-stranded DNA
por: Saini, Natalie, et al.
Publicado: (2020)

Somatic Hypermutation in Muts Homologue (Msh)3-, Msh6-, and Msh3/Msh6-Deficient Mice Reveals a Role for the Msh2–Msh6 Heterodimer in Modulating the Base Substitution Pattern
por: Wiesendanger, Margrit, et al.
Publicado: (2000)

RDR6 Is Essential for Double-Strand Break Formation during Male Meiosis in Rice
por: Zhan, Junpeng
Publicado: (2020)

A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression
por: van den Berg, Jeroen, et al.
Publicado: (2018)

CD40-deficient, Influenza-specific CD8 Memory T Cells Develop and Function Normally in a CD40-sufficient Environment
por: Lee, Byung O., et al.
Publicado: (2003)

MHC Class II Expression Restricted to CD8α(+) and CD11b(+) Dendritic Cells Is Sufficient for Control of Leishmania major
por: Lemos, Maria P., et al.
Publicado: (2004)

Constitutive Expression of AID Leads to Tumorigenesis
por: Okazaki, Il-mi, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_12rjiaqru2bil2ti6g3vitf3r3