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DNA Double-Strand Breaks: Prior to but not Sufficient in Targeting Hypermutation

The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination (CSR) of immunoglobulin (Ig) genes, both of which are associated with DNA double-strand breaks (DSBs). As AID is capable of deaminating deoxy-cytidine (dC) to deoxy-uracil (dU),...

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Detalles Bibliográficos
Autores principales:	Bross, Linda, Muramatsu, Masamichi, Kinoshita, Kazuo, Honjo, Tasuku, Jacobs, Heinz
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193713/ https://www.ncbi.nlm.nih.gov/pubmed/11994423 http://dx.doi.org/10.1084/jem.20011749

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